1096359-57-7

Basic information

• Product Name: {4-[2-(benzyl-ethyl-amino)-ethoxy]-phenyl}-(2-butyl-benzofuran-3-yl)-methanone
• Synonyms: {4-[2-(benzyl-ethyl-amino)-ethoxy]-phenyl}-(2-butyl-benzofuran-3-yl)-methanone
• CAS NO: 1096359-57-7
• Molecular Weight: 455.597
• Mol File: 1096359-57-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {4-[2-(benzyl-ethyl-amino)-ethoxy]-phenyl}-(2-butyl-benzofuran-3-yl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: {4-[2-(benzyl-ethyl-amino)-ethoxy]-phenyl}-(2-butyl-benzofuran-3-yl)-methanone(1096359-57-7)
• EPA Substance Registry System: {4-[2-(benzyl-ethyl-amino)-ethoxy]-phenyl}-(2-butyl-benzofuran-3-yl)-methanone(1096359-57-7)

Safety Data

• Hazardous Substances Data: 1096359-57-7(Hazardous Substances Data)

Upstream product

• 60154-59-8 benzyl-(2-chloro-ethyl)-ethyl-amine 
• 52490-15-0 2-n-Butyl-3-(4-hydroxy-benzoyl)-benzofuran 

Relevant articles and documents

Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites

Amiodarone (Cordarone, Wyeth-Ayerst Pharmaceuticals) is a clinically available drug used to treat a wide variety of cardiac arrhythmias. We report here the synthesis and characterization of a panel of potential amiodarone metabolites that have significant structural similarity to thyroid hormone and its metabolites the iodothyronamines. Several of these amiodarone derivatives act as specific agonists of the G protein-coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1). This result demonstrates a novel molecular target for amiodarone derivatives with potential clinical significance.