109803-52-3Relevant articles and documents
MTH1 INHIBITORS FOR TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS
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Page/Page column 61; 62, (2016/04/04)
A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.
Discovery of a potent small molecule IL-2 inhibitor through fragment assembly
Braisted, Andrew C.,Oslob, Johan D.,Delano, Warren L.,Hyde, Jennifer,McDowell, Robert S.,Waal, Nathan,Yu, Chul,Arkin, Michelle R.,Raimundo, Brian C.
, p. 3714 - 3715 (2007/10/03)
Using a site-directed fragment discovery method called tethering, we have identified a 60 nM small molecule antagonist of a cytokine/receptor interaction (IL-2/IL2Rα) with cell-based activity. Starting with a low micromolar hit, we employed a combination
Effects of [(N-alkyl-1,3-dioxo-1H,3H-isoindolin-5-yl)oxy]alkanoic acids, [(N-alkyl-1-oxo-1H,3H-isoindolin-5-yl)oxy]butanoic acids, and related derivative on chloride influx in primary astroglial cultures
Wyrick,Smith,Kemp,Grippo
, p. 1798 - 1806 (2007/10/02)
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