55901-80-9

Basic information

• Product Name: 2,3-dichloro-4-methoxy-benzoic acid
• Synonyms: 2,3-dichloro-4-methoxy-benzoic acid
• CAS NO: 55901-80-9
• Molecular Weight: 221.04
• Mol File: 55901-80-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2,3-dichloro-4-methoxy-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dichloro-4-methoxy-benzoic acid(55901-80-9)
• EPA Substance Registry System: 2,3-dichloro-4-methoxy-benzoic acid(55901-80-9)

Safety Data

• Hazardous Substances Data: 55901-80-9(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 54135-80-7 1,2,3-trichloro-4-methoxybenzene 
• 1984-59-4 2,3-dichloroanisole 
• 1940-44-9 4-bromo-2,3-dichlorophenol 
• 576-24-9 2,3-dichlorophenol 
• 109803-52-3 1-bromo-2,3-dichloro-4-methoxybenzene 

Downstream Products

• 76238-31-8 2,3-dichloro-4-methoxybenzoyl chloride 
• 164341-36-0 2,3-Dichloro-4-methoxybenzoylguanidine hydrochloride 
• 109804-13-9 4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester 
• 109804-10-6 4-(2,3-Dichloro-4-cyclopentylcarbamoyl-phenoxy)-butyric acid ethyl ester 
• 109804-45-7 4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid 
• 109804-42-4 4-(2,3-Dichloro-4-cyclopentylcarbamoyl-phenoxy)-butyric acid 
• 109803-56-7 N-methyl-N-cyclopentyl-2,3-dichloro-4-methoxybenzamide 
• 109803-57-8 N-methyl-N-cyclopentyl-2,3-dichloro-4-hydroxybenzamide 
• 109803-53-4 N-cyclopentyl-2,3-dichloro-4-methoxybenzamide 
• 109803-59-0 N-cyclopentyl-2,3-dichloro-4-hydroxybenzamide 
• 515846-52-3 (R)-[1-(2-{4-[5-(2,3-dichloro-4-methoxy-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Electrosynthesis of aryl-carboxylic acids from chlorobenzene derivatives and carbon dioxide

The electrocarboxylation of a large variety of chlorobenzenic compounds is achieved in N,N-dimethylformamide by constant current electrolysis between a stainless steel cathode and a sacrificial magnesium anode in a diaphragmless cell. Substituted benzoic acids are obtained in high yield in simle conditions thus avoiding the usual preparation of organometallic intermediates.

Discovery of a potent small molecule IL-2 inhibitor through fragment assembly

Using a site-directed fragment discovery method called tethering, we have identified a 60 nM small molecule antagonist of a cytokine/receptor interaction (IL-2/IL2Rα) with cell-based activity. Starting with a low micromolar hit, we employed a combination

2,3-Dichloro-4-hydroxy-benzoic acid and process for preparation thereof

A Reimer-Tiemann reaction of 2,3-dichlorophenol with carbon tetrachloride gives 2,3-dichloro-4-hydroxy-benzoic acid, a novel intermediate, which is then reacted with thiophene in the presence of phosphorus pentoxide or polyphosphoric acid to give 2,3-dichloro-4-(2-thienoyl)-phenol. This compound is then converted to the diuretic, ticrynafen, by known prior art reactions.