110098-09-4

Basic information

• Product Name: (4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-methyl-dihydro-furan-2-one
• Synonyms: (4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-methyl-dihydro-furan-2-one
• CAS NO: 110098-09-4
• Molecular Weight: 368.548
• Mol File: 110098-09-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-methyl-dihydro-furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-methyl-dihydro-furan-2-one(110098-09-4)
• EPA Substance Registry System: (4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-methyl-dihydro-furan-2-one(110098-09-4)

Safety Data

• Hazardous Substances Data: 110098-09-4(Hazardous Substances Data)

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 106757-56-6 (Z)-(-)-methyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate 
• 112837-17-9 (R)-(+)-5-(hydroxymethyl)furan-2(5H)-one 
• 917-54-4 methyllithium 
• 110171-24-9 (R)-5-(2,2-Dimethyl-1,1-diphenyl-propoxymethyl)-5H-furan-2-one 
• 140710-18-5 (1S^*,2S^*,3R^*)-2-(tert-butyldiphenylsiloxymethyl)-3-methylcyclobutanol 
• 140710-20-9 C₂₈H₄₄O₂Si₂ 
• 140710-22-1 2-(tert-butyldiphenylsiloxymethyl)-3-methylcyclobutanone 
• 110171-24-9 (R)-(+)-5-(tert-butyldiphenylsilanyloxymethyl)furan-2(5H)-one 

Downstream Products

• 112031-78-4 3,4-dideoxy-3-C-methyl-5-O-tert-butyldiphenylsilyl-D-erythro-pentitol 
• 202392-39-0 ((2R,3R,5R)-5-Allyl-3-methyl-tetrahydro-furan-2-ylmethoxy)-tert-butyl-diphenyl-silane 
• 202392-41-4 tert-Butyl-[(2R,3R,5R)-5-(3-methoxymethoxy-propyl)-3-methyl-tetrahydro-furan-2-ylmethoxy]-diphenyl-silane 
• 202392-40-3 3-[(2R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-methyl-tetrahydro-furan-2-yl]-propan-1-ol 
• 397886-62-3 2,2-Dimethyl-propionic acid 2-[(2S,4R,6S)-6-[(2E,9E)-(6R,7R)-11-hydroxy-6-(4-methoxy-benzyloxy)-7-methyl-undeca-2,9-dien-4-ynyl]-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-ethyl ester 
• 397886-47-4 (E)-(5R,6R)-6-(4-Methoxy-benzyloxy)-5-methyl-oct-2-en-7-yn-1-ol 
• 397886-60-1 Acetic acid (E)-(5R,6R)-7-(tert-butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5-methyl-hept-2-enyl ester 
• 397886-58-7 (E)-(5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5-methyl-hept-2-enoic acid methyl ester 
• 397886-59-8 (E)-(5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5-methyl-hept-2-en-1-ol 
• 397886-57-6 (E)-(5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-5-methyl-hept-2-enoic acid methyl ester 
• 397886-61-2 Acetic acid (E)-(5R,6R)-8,8-dibromo-6-(4-methoxy-benzyloxy)-5-methyl-octa-2,7-dienyl ester 
• 397886-67-8 Acetic acid (E)-(5R,6R)-7-hydroxy-6-(4-methoxy-benzyloxy)-5-methyl-hept-2-enyl ester 

Relevant articles and documents

Synthetic studies aimed at (-)-cochleamycin A. Evaluation of late-stage macrocyclization alternatives

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Synthetic study on gymnodimine: Highly stereoselective construction of substituted tetrahydrofuran and cyclohexene moieties

The synthetic studies on gymnodimine, a shellfish toxin, are described. This marine toxin consists of 16-membered carbocycle, tetrahydrofuran, and spiro-imine moieties. Our synthetic strategy involves the stereoselective allylation of tetrahydrofuran compound and the exo-selective intramolecular Diels-Alder reaction.

Stereospecificity in Allergic Contact Dermatitis to Simple Substituted Methylene Lactone Derivatives

The enantiomers of β,γ-dimethyl- and β-methyl-α-methylene-γ-butyrolactones have been synthesized stereospecifically from glutamic acid and β-hydroxy isobutyric acid, respectively.Guinea pigs have been sensitized (Freund complete adjuvant technique) and tested to them.Both enantiomers of β-methyl lactone as well as (+)-β,γ-dimethyl lactone induced enantiospecific allergic contact dermatitis (ACD); in turn, (-)-β,γ-dimethyl lactone showed no specificity.An interpretation is proposed.