110486-69-6

Basic information

• Product Name: Quinoline, 2-chloro-3-(phenylmethyl)-
• Synonyms: Quinoline,2-chloro-3-(phenylmethyl);3-benzyl-2-chloro-quinoline;3-Benzyl-2-chlor-chinolin
• CAS NO: 110486-69-6
• Molecular Formula: C16H12ClN
• Molecular Weight: 253.731
• Mol File: 110486-69-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 74-75 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 389.6±27.0 °C(Predicted)
• Density: 1.219±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Quinoline, 2-chloro-3-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 2-chloro-3-(phenylmethyl)-(110486-69-6)
• EPA Substance Registry System: Quinoline, 2-chloro-3-(phenylmethyl)-(110486-69-6)

Safety Data

• Hazardous Substances Data: 110486-69-6(Hazardous Substances Data)

Upstream product

• 3271-81-6 hydrocinnamanilide 
• 68-12-2 N,N-dimethyl-formamide 
• 645-45-4 hydrocinnamic acid chloride 
• 606146-00-3 2-(3-phenyl-1-propynyl)formanilide 
• 105479-98-9 ethyl 2-(acetoxy(phenyl)methyl)acrylate 
• 37442-45-8 ethyl 2-(hydroxy(phenyl)methyl)propenoate 
• 924658-08-2 2-(phenyl-phenylamino-methyl)-acrylic acid ethyl ester 
• 101273-50-1 3-benzylquinolin-2-ol 

Downstream Products

• 37045-16-2 3-benzylquinoline 
• 1381767-10-7 3-benzyl-2-methoxyquinoline 
• 106835-49-8 2-Methoxy-3-<(α-phenyl)bromomethyl>quinoline 
• 870070-56-7 3-benzyl-2-iodoquinoline 
• 110487-31-5 [2-(3-Benzyl-quinolin-2-ylsulfanyl)-ethyl]-dimethyl-amine 

Relevant articles and documents

Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-Dimethylaminomethyl)phenyl)quinoline-Derived Antitubercular Lead Compounds

Bedaquiline (BDQ) is a novel and highly potent last-line antituberculosis drug that was approved by the US FDA in 2013. Owing to its stereo-structural complexity, chemical synthesis and compound optimization are rather difficult and expensive. This study

Trifluoroacetic acid: a more effective and efficient reagent for the synthesis of 3-arylmethylene-3,4-dihydro-1H-quinolin-2-ones and 3-arylmethyl-2-amino-quinolines from Baylis-Hillman derivatives via Claisen rearrangement

Trifluoroacetic acid has been discovered to be a highly effective and efficient reagent for the tandem Claisen rearrangement and cyclization reaction to yield 3-arylmethylene-3,4-dihydro-1H-quinolin-2-ones from compounds obtained from the SN2 r