110931-32-3

Basic information

• Product Name: L-Proline, 1-[2-hydroxy-1-oxo-6-[[(phenylmethoxy)carbonyl]amino]hexyl]-, phenylmethyl ester, (S)-
• CAS NO: 110931-32-3
• Molecular Formula: C26H32N2O6
• Molecular Weight: 468.55
• Mol File: 110931-32-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-[2-hydroxy-1-oxo-6-[[(phenylmethoxy)carbonyl]amino]hexyl]-, phenylmethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-[2-hydroxy-1-oxo-6-[[(phenylmethoxy)carbonyl]amino]hexyl]-, phenylmethyl ester, (S)-(110931-32-3)
• EPA Substance Registry System: L-Proline, 1-[2-hydroxy-1-oxo-6-[[(phenylmethoxy)carbonyl]amino]hexyl]-, phenylmethyl ester, (S)-(110931-32-3)

Safety Data

• Hazardous Substances Data: 110931-32-3(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 42491-84-9 (S)-6-Amino-2-hydroxyhexanoic acid 
• 59221-35-1 (S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid 
• 41324-66-7 H-Pro-OBzl 

Downstream Products

• 111223-26-8 ceronapril 
• 111496-54-9 1-<(S)-2-<oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester 
• 111496-77-6 (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(butyl-hydroxy-phosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 111496-61-8 (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(hydroxy-pentyl-phosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 111496-75-4 (S)-1-{(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-methyl-pentyl)-phosphinoyloxy]-hexanoyl}-pyrrolidine-2-carboxylic acid benzyl ester 
• 111496-63-0 (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(hexyl-hydroxy-phosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 111496-65-2 (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(heptyl-hydroxy-phosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 111496-67-4 (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(hydroxy-octyl-phosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 111496-69-6 (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(hydroxy-nonyl-phosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester 

Relevant articles and documents

(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]- -proline, a novel orally active inhibitor of ACE

The synthesis of a series of orally active, phosphinyloxyacyl proline inhibitors of angiotensin converting enzyme (ACE) is described. The in vitro and in vivo ACE inhibitory activities are reported for each compound. The structure-activity relationship fo