59221-35-1

Basic information

• Product Name: Z-oxylysine
• Synonyms: Z-oxylysine
• CAS NO: 59221-35-1
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.30436
• Mol File: 59221-35-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 521.5°C at 760 mmHg
• Flash Point: 269.2°C
• Appearance: /
• Density: 1.244g/cm³
• Vapor Pressure: 1.05E-11mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: Z-oxylysine(CAS DataBase Reference)
• NIST Chemistry Reference: Z-oxylysine(59221-35-1)
• EPA Substance Registry System: Z-oxylysine(59221-35-1)

Safety Data

• Hazardous Substances Data: 59221-35-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H19NO5/c16-12(13(17)18)8-4-5-9-15-14(19)20-10-11-6-2-1-3-7-11/h1-3,6-7,12,16H,4-5,8-10H2,(H,15,19)(H,17,18)/t12-/m0/s1

Upstream product

• 42491-84-9 (S)-6-Amino-2-hydroxyhexanoic acid 
• 501-53-1 benzyl chloroformate 
• 102390-88-5 6-benzyloxycarbonylamino-2-oxo-hexanoic acid 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 657-27-2 L-Lysine hydrochloride 

Downstream Products

• 126110-92-7 (2S,3aS,7aS)-1-((S)-6-Benzyloxycarbonylamino-2-hydroxy-hexanoyl)-octahydro-indole-2-carboxylic acid ethyl ester 
• 126110-93-8 (2S,3aS,6aS)-1-((S)-6-Benzyloxycarbonylamino-2-hydroxy-hexanoyl)-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester 
• 126110-91-6 <1(R^*),2α,4α>-4-cyclohexyl-1-<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester 
• 126110-91-6 (2S,4S)-1-((S)-6-Benzyloxycarbonylamino-2-hydroxy-hexanoyl)-4-cyclohexyl-pyrrolidine-2-carboxylic acid benzyl ester 
• 126187-84-6 {4-[(S)-2,5-Dioxo-2-(4-phenyl-butyl)-2λ⁵-[1,3,2]dioxaphospholan-4-yl]-butyl}-carbamic acid benzyl ester 
• 126111-16-8 (S)-6-Benzyloxycarbonylamino-2-(2,2-dimethyl-propionyloxy)-hexanoic acid 
• 126111-17-9 (S)-2-(acetyloxy)-6-<<(phenylmethoxy)carbonyl>amino>hexanoic acid 
• 107492-32-0 (S)-2-hydroxy-6<<(phenylmethoxy)carbonyl>amino>hexanoic acid methyl ester 
• 110931-32-3 1-<(S)-2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester 
• 64803-24-3 [(S)-6-(2,5-Dioxo-pyrrolidin-1-yl)-5-hydroxy-6-oxo-hexyl]-carbamic acid benzyl ester 
• 250383-35-8 6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester 
• 250383-42-7 (S)-1-((R)-6-Benzyloxycarbonylamino-2-hydroxy-hexanoyl)-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 42491-84-9 (S)-6-Amino-2-hydroxyhexanoic acid 
• 111223-31-5 (S)-6-(tert-butyloxycarbonylamino)-2-hydroxyhexanoic acid 

Relevant articles and documents

Development of a safe gene delivery system using biodegradable polymer, poly[α-(4-aminobutyl)-L-glycolic acid] [19]

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Pluronic-poly[α-(4-aminobutyl)-l-glycolic acid] polymeric micelle-like nanoparticles as carrier for drug delivery

Pluronic-poly[α-(4-aminobutyl)-l-glycolic acid] (Pluronic-PAGA) with different types of Pluronic, the different molecule weight of PAGA, and the different molar ratios of Pluronic to PAGA were synthesized. These materials were bio-degradable, amphiphilic, could be degraded into non-toxic small molecules and could be used to carry drugs. 5-Fluorouracil (5-Fu) loaded Pluronic-PAGA micellelike nanoparticles (5-Fu loaded P-PAGA NPs) were prepared by a simple self-assembly method, and characterized by dynamic light scattering, transmission electron microscope. The degradation and release characteristics have also been studied in this paper. With the time passing, the 5-Fu loaded P-PAGA NPs degraded into smaller ones with the similar characteristics of the original NPs. Both the types of Pluronic and the molecule weight of the PAGA affected the releasing progresses. It was found that 5-Fu loaded P-PAGA NPs exhibited high growth inhibitory effect on human gastric cancer cells by MTT assay. The cellular uptake of Rhodamine B loaded P-PAGA NPs was higher than free Rhodamine B. This study suggested that the Pluronic-PAGA with acceptable drug entrapment efficiencies, drug loading efficiencies and tunable release profiles could offer an alternative carrier for 5-Fu delivery and have the potential for the delivery of other anti-tumour drug. Copyright

Conformational studies on peptides of α-aminoxy acids with functionalized side-chains

Peptides of homochiral α- aminoxy acids of nonpolar side chains can form a 1.88-helix. In this paper, we report the conformational studies of α- aminoxy peptides 1-3, which have functionalized side chains, in both non- polar and polar solvents.

Synthesis of optically active phthaloyl D-aminooxy acids from L-amino acids or L-hydroxy acids as building blocks for the preparation of aminooxy peptides

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