110972-15-1

Basic information

• Product Name: N-(2,2,2-trifluoro-1-methoxyethyl)-N-methylaniline
• CAS NO: 110972-15-1
• Molecular Weight: 219.207
• Mol File: 110972-15-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2,2,2-trifluoro-1-methoxyethyl)-N-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2,2-trifluoro-1-methoxyethyl)-N-methylaniline(110972-15-1)
• EPA Substance Registry System: N-(2,2,2-trifluoro-1-methoxyethyl)-N-methylaniline(110972-15-1)

Safety Data

• Hazardous Substances Data: 110972-15-1(Hazardous Substances Data)

Upstream product

• 431-46-9 2,2,2-trifluoro-1-methoxy-ethanol 
• 100-61-8 N-methylaniline 
• 345-81-3 2,2,2-Trifluoro-N-methyl-N-phenyl-acetamide 
• 55204-33-6 N-methyl-N-(2,2,2-trifluoroethyl)-aniline 
• 67-56-1 methanol 

Downstream Products

• 55204-33-6 N-methyl-N-(2,2,2-trifluoroethyl)-aniline 

Relevant articles and documents

Trifluoroacetaldehyde: A useful industrial bulk material for the synthesis of trifluoromethylated amino compounds

The synthesis of various trifluoromethylated amino compounds was studied using trifluoroacetaldehyde, an industrial bulk material, as a starting compound. One general application of trifluoroacetaldehyde is the preparation of trifluoroethylamino derivatives via reductive amination reaction. This synthesis includes the formation of the corresponding N,O-acetal intermediates followed by their reduction using NaBH4 or 2-picoline borane complex, affording the target trifluoroethylamino compounds in moderate to good yields (47-87%). Another general application of trifluoroacetaldehyde is the synthesis of chiral α-substituted trifluoroethylamino compounds. In this synthesis, trifluoroacetaldehyde was first converted into the chiral trifluoromethyl tert-butyl sulfinimine, which was subjected to 1,2-nucleophilic addition reactions across its C{double bond, long}N double bond. The addition of phenyllithium afforded α-(phenyl)trifluoroethylamino derivative in 83% yield and with 96% de. Allylation and Reformatsky reactions produced the corresponding α-substituted trifluoroethylamino derivatives in 82 and 58% yields and with 90 and 91% de, respectively.

Electrolytic Transformation of Fluoroorganic Compounds. 3. Highly Regioselective Anodic Methoxylation of N-(2,2,2-trifluoroethyl)amines

Anodic methoxylation of N-alkyl-N-(2,2,2-trifluoroethyl)anilines and N-(2,2,2-trifluoroethyl)diphenylamine places the methoxy group in the α-position (toward the trifluoromethyl group); these products are useful building blocks for the construction of a c