55204-33-6

Basic information

• Product Name: Benzenamine, N-methyl-N-(2,2,2-trifluoroethyl)-
• CAS NO: 55204-33-6
• Molecular Formula: C9H10F3N
• Molecular Weight: 189.18
• Mol File: 55204-33-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenamine, N-methyl-N-(2,2,2-trifluoroethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N-methyl-N-(2,2,2-trifluoroethyl)-(55204-33-6)
• EPA Substance Registry System: Benzenamine, N-methyl-N-(2,2,2-trifluoroethyl)-(55204-33-6)

Safety Data

• Hazardous Substances Data: 55204-33-6(Hazardous Substances Data)

Upstream product

• 100-61-8 N-methylaniline 
• 76-05-1 trifluoroacetic acid 
• 373-88-6 2,2,2-trifluroethylamine hydrochloride 
• 1547-96-2 2,4,6-tris(2,2,2-trifluoroethoxy)-1,3,5-triazine 
• 110972-15-1 N-(2,2,2-trifluoro-1-methoxyethyl)-N-methylaniline 
• 345-81-3 2,2,2-Trifluoro-N-methyl-N-phenyl-acetamide 

Downstream Products

• 126422-69-3 4-cyano-N-methyl-N-(2,2,2-trifluoroethyl)aniline 
• 126422-68-2 2-cyano-N-methyl-N-(2,2,2-trifluoroethyl)aniline 
• 126422-67-1 N-(cyanomethyl)-N-(2,2,2-trifluoroethyl)aniline 
• 126422-70-6 4,4'-bisbiphenyl 
• 110972-15-1 N-(2,2,2-trifluoro-1-methoxyethyl)-N-methylaniline 
• 351-61-1 N-(2,2,2-trifluoroethyl)-aniline 

Relevant articles and documents

Iron porphyrin-catalyzedN-trifluoroethylation of anilines with 2,2,2-trifluoroethylamine hydrochloride in aqueous solution

An iron porphyrin-catalyzedN-trifluoroethylation of anilines has been developed with 2,2,2-trifluoroethylamine hydrochloride as the fluorine source. This one-pot N-H insertion reaction is conductedviacascade diazotization/N-trifluoroethylation reactions.

Method of catalyzing trifluoro-ethylation of aromatic secondary amine by ferriporphyrin

The invention provides a method of catalyzing trifluoro-ethylation of aromatic secondary amine by ferriporphyrin. The method comprises the following steps: adding trifluoroethylamine salt and nitriteto a diazo-reaction first and then adding aromatic prima

Trifluoroacetaldehyde: A useful industrial bulk material for the synthesis of trifluoromethylated amino compounds

The synthesis of various trifluoromethylated amino compounds was studied using trifluoroacetaldehyde, an industrial bulk material, as a starting compound. One general application of trifluoroacetaldehyde is the preparation of trifluoroethylamino derivatives via reductive amination reaction. This synthesis includes the formation of the corresponding N,O-acetal intermediates followed by their reduction using NaBH4 or 2-picoline borane complex, affording the target trifluoroethylamino compounds in moderate to good yields (47-87%). Another general application of trifluoroacetaldehyde is the synthesis of chiral α-substituted trifluoroethylamino compounds. In this synthesis, trifluoroacetaldehyde was first converted into the chiral trifluoromethyl tert-butyl sulfinimine, which was subjected to 1,2-nucleophilic addition reactions across its C{double bond, long}N double bond. The addition of phenyllithium afforded α-(phenyl)trifluoroethylamino derivative in 83% yield and with 96% de. Allylation and Reformatsky reactions produced the corresponding α-substituted trifluoroethylamino derivatives in 82 and 58% yields and with 90 and 91% de, respectively.