1113-57-1

Basic information

• Product Name: 2-methylbutyramide
• Synonyms: 2-methylbutyramide
• CAS NO: 1113-57-1
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 0
• Mol File: 1113-57-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 232°Cat760mmHg
• Flash Point: 94.1°C
• Appearance: /
• Density: 0.901g/cm³
• Vapor Pressure: 0.0605mmHg at 25°C
• Refractive Index: 1.425
• CAS DataBase Reference: 2-methylbutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylbutyramide(1113-57-1)
• EPA Substance Registry System: 2-methylbutyramide(1113-57-1)

Safety Data

• Hazardous Substances Data: 1113-57-1(Hazardous Substances Data)

Usage

General Description

2-methylbutyramide, also known as 2-methylbutyramide, is a chemical compound with the molecular formula C5H11NO. It is a carboxylic acid amide with a unique structure consisting of a butyramide group with a methyl substitution at the 2-position. 2-methylbutyramide has a strong, pungent odor and is commonly used as a flavoring agent in food and beverages due to its nutty and creamy characteristics. It is also utilized in the production of perfumes, cosmetics, and pharmaceuticals due to its pleasant scent. Additionally, 2-methylbutyramide is found in a variety of natural sources, including cheese, meat, and butter, and is a key contributor to the overall sensory experience of these products.

InChI:InChI=1/C5H11NO/c1-3-4(2)5(6)7/h4H,3H2,1-2H3,(H2,6,7)

Upstream product

• 18936-17-9 2-methylbutanenitrile 
• 5856-79-1 iso-butyl chloroformate 
• 108-12-3 isopentanoyl chloride 
• 319-78-8 isoleucine 
• 590-18-1 (Z)-2-Butene 
• 77287-34-4 formamide 
• 116-53-0 2-Methylbutanoic acid 
• 64-17-5 ethanol 
• 34907-96-5 Trichlor-butadien-(1.3)-carbonsaeure-⁽²⁾-chlorid 
• 34907-98-7 1.1.3-Trichlor-butadien-(1.3)-carbonsaeure-⁽²⁾ 
• 16668-14-7 4,4-dichloro-3-trichloromethyl-but-3-en-2-one 
• 33966-50-6 SEC-BUTYLAMINE 
• 97-61-0 2-Methylpentanoic acid 
• 106-98-9 1-butylene 

Downstream Products

• 39076-02-3 Methyl N-sec-butylcarbamate 
• 18936-17-9 2-methylbutanenitrile 

Relevant articles and documents

-

-

Efficient heterogeneous hydroaminocarbonylation of olefins with ammonium chloride as amino source

An efficient protocol for heterogeneous hydroaminocarbonylation of olefins with ammonium chloride without addition of acid additive has been developed for the first time. We successfully synthesized the Pd@POPs-PPh3 catalyst through a solvothermal synthetic method. Under this heterogeneous catalytic system, C2-C6 olefins displayed good yields and TON, and a yield of 66% of propionamide and TON = 1400 were obtained under mild reaction conditions (403 K, Pethylene = 0.5 MPa, PCO = 2.5 MPa), which is a little higher than those in the homogeneous system. This catalytic system has the advantage of easy separation of product and catalyst, as well as good stability. Uniform dispersion of Pd active sites, strong coordination bond between P and Pd, high surface area, large pore volume and hierarchical porosity of Pd@POPs-PPh3 were confirmed by a series of characterizations, which is believed to be the keys for the good activity and stability of hydroaminocarbonylation reaction.

Copper(II)-Catalyzed Reactions of α-Keto Thioesters with Azides via C-C and C-S Bond Cleavages: Synthesis of N-Acylureas and Amides

Cu(II)-catalyzed reaction of α-keto thioesters with trimethylsilyl azide (TMSN3) proceeds with the transformation of the thioester group into urea through C-C and C-S bond cleavages, constituting a practical and straightforward synthesis of N-acylureas. When diphenyl phosphoryl azide (DPPA) is used instead as the azide source in an aqueous environment, primary amides are formed via substitution of the thioester group. The reactions are proposed to proceed through Curtius rearrangement of the initially formed α-keto acyl azide to generate an acyl isocyanate intermediate, which reacts further with an additional amount of azide or water and rearranges to afford the corresponding products. To demonstrate the potentiality of the method, one-step syntheses of pivaloylurea and isovaleroylurea, displaying anticonvulsant activities, have been carried out.

Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues

Valproic acid (VPA, 1) is a major broad spectrum antiepileptic and central nervous system drug widely used to treat epilepsy, bipolar disorder, and migraine. VPA's clinical use is limited by two severe and lifethreatening side effects, teratogenicity and hepatotoxicity. A number of VPA analogues and their amide, N-methylamide and urea derivatives, were synthesized and evaluated in animal models of neuropathic pain and epilepsy. Among these, two amide and two urea derivatives of 1 showed the highest potency as antineuropathic pain compounds, with ED50 values of 49 and 51 mg/kg for the amides (19 and 20) and 49 and 74 mg/kg for the urea derivatives (29 and 33), respectively. 19, 20, and 29 were equipotent to gabapentin, a leading drug for the treatment of neuropathic pain. These data indicate strong potential for the above-mentioned novel compounds as candidates for future drug development for the treatment of neuropathic pain. 2009 American Chemical Society.