111737-43-0

Basic information

• Product Name: Pyridinium, 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-4-methyl-1-(phenylmethyl)-, chloride
• CAS NO: 111737-43-0
• Molecular Formula: C18H21N2O.Cl
• Molecular Weight: 316.831
• Mol File: 111737-43-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyridinium, 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-4-methyl-1-(phenylmethyl)-, chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridinium, 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-4-methyl-1-(phenylmethyl)-, chloride(111737-43-0)
• EPA Substance Registry System: Pyridinium, 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-4-methyl-1-(phenylmethyl)-, chloride(111737-43-0)

Safety Data

• Hazardous Substances Data: 111737-43-0(Hazardous Substances Data)

Upstream product

• 68981-86-2 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine 
• 111736-38-0 C₁₁H₁₅N₂O^(1-)*Li⁽¹⁺⁾ 
• 100-44-7 benzyl chloride 
• 68981-84-0 3-(4',4'-dimethyl-4',5'-dihydro-oxazol-2'-yl)-4-methylpyridine 
• 555-16-8 4-nitrobenzaldehdye 
• 111737-51-0 1-Benzyl-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-4-methyl-1,4-dihydro-pyridine 

Downstream Products

• 111737-51-0 1-Benzyl-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-4-methyl-1,4-dihydro-pyridine 

Relevant articles and documents

NOUVEAUX MODELES DU NADH EN SERIE OXAZOLYL-3 DIHYDRO-1,4 PYRIDINE: SYNTHESE, REACTIVITE, ROLE DE LA COMPLEXATION DANS LA REACTIVITE

A new class of NADH models is described: they contain the 3-oxazolyl-1,4-dihydropyridine structure.They have been synthesized by regioselective addition at the 4 position of organometallic derivatives (one of them bearing a chiral group) on 3-(4,4-dimethyl-2-oxazolyl)pyridine.The 1,4-dihydropyridine structure is obtained after quaternarization and reduction by sodium dithionite.Quaternarization through Zincke's reaction leads to models having a chiral group at the pyridine nitrogen.This chirality is necessary to induce asymmetry at the 4 carbon in the corresponding 1,4-dihydropyridine.This asymmetry plays an important role in the low enantioselectivity of reduction of a prochiral substrate such as methyl benzoylformate.The chemical reactivity of the models has been studied by performing the reduction of p-nitrobenzaldhyde in the presence of magnesium perchlorate.All models gave quantitative yields.However, reactions are slower than those performed, in the same conditions, with N-benzyl-1,4-dihydronicotinamide (BNAH).A 13C nmr study shows that this behaviour is probably a consequence of the high complexation of magnesium with the oxazoline moiety.