68981-84-0

Basic information

• Product Name: 3-(4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOL-2-YL)-4-METHYLPYRIDINE
• Synonyms: 3-(4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOL-2-YL)-4-METHYLPYRIDINE;3-(4,4-Dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-methylpyridine , tech;3-(4,5-Dihydro-4,4-dimethyl-1,3-oxazol-2-yl)-4-methylpyridine;3-(4,5-Dihydro-4,4-dimethyl-1,3-oxazol-2-yl)-4-picoline;3-(4,4-DiMethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-Methylpyridine, 95;4,5-Dihydro-4,4-dimethyl-2-(4-methylpyridin-3-yl)-1,3-oxazole, 3-(4,5-Dihydro-4,4-dimethyl-1,3-oxazol-2-yl)-4-picoline;3-(4,4-Dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-methylpiridine;3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-4-methyl-pyridine
• CAS NO: 68981-84-0
• Molecular Formula: C₁₁H₁₄N₂O
• Molecular Weight: 190.24
• Mol File: 68981-84-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 309.4ºC at 760 mmHg
• Flash Point: 140.9ºC
• Appearance: /
• Density: 1.11g/cm3
• Vapor Pressure: 0.00117mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 3-(4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOL-2-YL)-4-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOL-2-YL)-4-METHYLPYRIDINE(68981-84-0)
• EPA Substance Registry System: 3-(4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOL-2-YL)-4-METHYLPYRIDINE(68981-84-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 68981-84-0(Hazardous Substances Data)

Usage

General Description

3-(4,4-Dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-methylpyridine is a chemical compound with the molecular formula C13H16N2O. It is a derivative of pyridine and oxazoline and possesses a heterocyclic structure. 3-(4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOL-2-YL)-4-METHYLPYRIDINE is used in the pharmaceutical industry as a building block for the synthesis of various organic compounds. It may also have applications in the field of medicinal chemistry for the development of new drugs and active pharmaceutical ingredients. 3-(4,4-Dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-methylpyridine should be handled with care and proper safety precautions, as it may be hazardous if not used properly.

InChI:InChI=1/C11H14N2O/c1-8-4-5-12-6-9(8)10-13-11(2,3)7-14-10/h4-6H,7H2,1-3H3

Upstream product

• 68981-79-3 3-(4,4-dimethyloxazolin-2-yl)-4-methyl-1,4-dihydropyridine 
• 111736-38-0 C₁₁H₁₅N₂O^(1-)*Li⁽¹⁺⁾ 
• 917-54-4 methyllithium 
• 68981-86-2 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine 
• 59-67-6 nicotinic acid 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 

Downstream Products

• 111737-43-0 1-Benzyl-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-4-methyl-pyridinium; chloride 
• 94015-05-1 4-methylpyridine-3-carboxylic acid hydrochloride 
• 155136-54-2 4-methylnicotinoyl chloride 
• 111737-51-0 1-Benzyl-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-4-methyl-1,4-dihydro-pyridine 

Relevant articles and documents

Cholinergic agents: Effect of methyl substitution in a series of arecoline derivatives on binding to muscarinic acetylcholine receptors

Arecoline, arecaidine, and a series of derivatives, differing by the presence or absence of methyl groups at positions on the periphery of the molecule, were prepared, and their binding to muscarinic acetylcholine receptors was tested. On the basis of this study, muscarinic agonism for arecoline series is governed by strict structure-activity relationships, as previously observed for other agonist series. Only minor changes in nitrogen substitution were tolerated in the present series of arecoline derivatives.

The Addition-Elimination Mechanism in the Nucleophilic Heteroaromatic Substitution of 3-(4',4'-Dimethyl-4',5'-dihydro-oxazol-2'-yl)pyridine. Solvent Effect on the Regiochemistry of the Addition Reaction

The nucleophilic heteroaromatic substitution of 3-(4',4'-dimethyl-4',5'-dihydro-oxazol-2'-yl)pyridine (3) with organolithium compounds has been studied.The reaction of (3) with butyl-lithium gave a mixture of the corresponding 2,3-, 3,4-, and 2,5-disubsti

Regioselective Nucleophilic Addition of Organolithium Compounds to 3-(4,4-Dimethyloxazolin-2-yl)pyridine

The nucleophilic heteroaromatic addition reactions of 3-(4,4-dimethyloxazolin-2-yl)pyridine (8) with organolithium compounds as nucleophilic reagents have been investigated.Strongly nucleophilic reagents have been observed to add preferentially to the γ-