111770-90-2

Basic information

• Product Name: 5-bromo-2-(3,4-dimethoxyphenyl)pyridine
• Synonyms: 5-bromo-2-(3,4-dimethoxyphenyl)pyridine
• CAS NO: 111770-90-2
• Molecular Formula: C₁₃H₁₂BrNO₂
• Molecular Weight: 294
• Mol File: 111770-90-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 65-67 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
• Boiling Point: 362.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.386±0.06 g/cm3(Predicted)
• PKA: 2.86±0.27(Predicted)
• CAS DataBase Reference: 5-bromo-2-(3,4-dimethoxyphenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-(3,4-dimethoxyphenyl)pyridine(111770-90-2)
• EPA Substance Registry System: 5-bromo-2-(3,4-dimethoxyphenyl)pyridine(111770-90-2)

Safety Data

• Hazardous Substances Data: 111770-90-2(Hazardous Substances Data)

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 2859-78-1 4-Bromoveratrole 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 895154-77-5 tris(3,4-dimethoxyphenyl)bismuthane 
• 223463-13-6 2-iodo-5-bromopyridine 

Downstream Products

• 953434-78-1 (E)-tert-butyl 3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylate 

Relevant articles and documents

Cross-coupling study of iodo/chloropyridines and 2-chloroquinoline with atom-economic triarylbismuth reagents under Pd-catalysis

This study describes the palladium-catalyzed couplings of iodopyridines, chloropyridines, and chloroquinoline with atom-economic BiAr3 reagents in sub-stoichiometric loadings. Mono-arylations of iodo and chloropyridines produced arylpyridines i

BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE

The invention relates to the inhibition of histone deacetylase. The invention provides compounds which are derivatives of benzamide and suitable in methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions .

A Convenient Palladium-Catalyzed Coupling Approach to 2,5-Disubstituted Pyridines

2,5-Dibromopyridine has been found to undergo a regioselective palladium-catalyzed coupling reaction with terminal acetylenes and arylzinc halides to give the corresponding 2-alkynyl-5-bromo- and 2-aryl-5-bromopyridines, respectively, in 70percent-90percent isolated yields.To complement this chemistry, the triflate derived from 2-methyl-5-pyridinol was found to participate in a palladium-catalyzed reaction with terminal acetylenes leading to the corresponding 5-alkynyl-2-methylpyridines.These intermediates can be further manipulated to afford a broad range of 2,5-disubstituted pyridines.