223463-13-6 Usage
Description
5-Bromo-2-iodopyridine is a light yellow crystalline compound that serves as an important intermediate in the synthesis of various organic compounds and pharmaceuticals. Its unique structure, featuring a bromine atom at the 5-position and an iodine atom at the 2-position on the pyridine ring, allows for versatile chemical reactions and applications.
Uses
Used in Organic Synthesis:
5-Bromo-2-iodopyridine is used as a key intermediate for the synthesis of various organic compounds, including:
1. 5-bromopyridyl-2-magnesium chloride, which is prepared through a reaction with isopropylmagnesium chloride solution. 5-Bromo-2-iodopyridine can be further utilized in the synthesis of other organic molecules and pharmaceuticals.
2. 5-bromo-2-pyridylzinc iodide, obtained by treating 5-bromo-2-iodopyridine with active zinc in tetrahydrofuran. This reagent can be employed in various cross-coupling reactions to form new carbon-carbon or carbon-heteroatom bonds.
3. 5-bromo-2-(trifluoromethyl)pyridine, produced via a halogen/trifluoromethyl displacement reaction. 5-Bromo-2-iodopyridine can be used as a building block for the synthesis of trifluoromethylated pyridine derivatives, which are valuable in medicinal chemistry and materials science.
4. (5-bromopyridin-2-yl)zinc(II) chloride, synthesized through a multi-step process. 5-Bromo-2-iodopyridine can be used as a versatile reagent in various organic transformations.
5. 5,5′-dibromo-2,2′-bipyridine, also synthesized through a multi-step process. 5-Bromo-2-iodopyridine can be employed in the construction of ligands for coordination complexes, which have applications in catalysis, sensing, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 223463-13-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,4,6 and 3 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 223463-13:
(8*2)+(7*2)+(6*3)+(5*4)+(4*6)+(3*3)+(2*1)+(1*3)=106
106 % 10 = 6
So 223463-13-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H3BrIN/c6-4-1-2-5(7)8-3-4/h1-3H
223463-13-6Relevant articles and documents
Improved synthesis of 5,5"-dibromo-2,2′:6′,2"-terpyridine
Colasson, Beno?t X.,Dietrich-Buchecker, Christiane,Sauvage, Jean-Pierre
, p. 271 - 272 (2002)
5,5"-dibromo-2,2′:6′,2"-terpyridine has been synthesized in very good yield and on a multigram scale modifying the Stille cross-coupling strategy published by Schlüter and coworkers in a previous work.
ELECTROCHROMIC COMPOUNDS AND OPTICAL ARTICLES CONTAINING THEM
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Page/Page column 20; 21, (2018/07/31)
The present invention relates to a group of novel electrochromic compounds. More specifically, it relates to electrochromic compounds comprising one or several pyridinium rings and the use of these compounds as a variable transmittance medium for the manufacture of an optical article, such as an ophthalmic lens.
Hybrid charged heterometallic Pt-Ir complexes: Tailoring excited states by taking the best of both worlds
Soliman, Ahmed M.,Fortin, Daniel,Harvey, Pierre D.,Zysman-Colman, Eli
supporting information; experimental part, p. 1120 - 1122 (2012/03/10)
The CC-linkage of Pt(PR3)2(CCAr)2 with (CN)2Ir(NN)+ (CN = 2-phenylpyridine; NN = bipyridyl) leads to hetero-bi- and trimetallic species exhibiting photophysical properties reminiscent of both [Pt]- and [Ir]-containing moieties through the generation of a [Pt] → [Ir] charge transfer excited state. The Royal Society of Chemistry 2012.