111869-49-9

Basic information

• Product Name: 7-Deaza-ddG
• Synonyms: 7-Deaza-ddG
• CAS NO: 111869-49-9
• Molecular Formula: C11H14N4O3
• Molecular Weight: 250.25386
• EINECS: -0
• Mol File: 111869-49-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 228 °C (decomp)
• Appearance: /
• Density: 1.75±0.1 g/cm3(Predicted)
• PKA: 11.29±0.20(Predicted)
• CAS DataBase Reference: 7-Deaza-ddG(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Deaza-ddG(111869-49-9)
• EPA Substance Registry System: 7-Deaza-ddG(111869-49-9)

Safety Data

• Hazardous Substances Data: 111869-49-9(Hazardous Substances Data)

Usage

General Description

7-Deaza-ddG, also known as 7-Deaza-2'-deoxyguanosine, is a modified nucleoside primarily used in chemical synthesis and molecular biology research. It is commonly used in the preparation of modified oligonucleotides and as a tool for investigating the structure and function of DNA and RNA. 7-Deaza-ddG is valuable for its ability to disrupt hydrogen bonding between nucleotides, making it useful for studying the interactions between DNA and proteins. Additionally, 7-Deaza-ddG has been explored for its potential therapeutic applications, such as in the development of antiviral drugs. Overall, this chemical plays a crucial role in advancing our understanding of nucleic acids and has the potential to contribute to the development of new medical treatments.

Upstream product

• 120552-07-0 2-amino-4-chloro-7-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine 
• 111869-45-5 7-(2,3-Didesoxy-β-D-glycero-pentofuranosyl)-2-<(dimethylamino)methylenamino>-3,7-dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-on 
• 111869-48-8 7-(2,3-Didesoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-glycero-pentofuranosyl)-2-<(4,4'-dimethoxytriphenylmethyl)amino>-3,7-dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-on 
• 86392-75-8 7-deaza-2'-deoxyguanosine 
• 111902-68-2 7-(2-Desoxy-β-D-erythro-pentofuranosyl)-2-<(dimethylamino)methylenamino>-3,7-dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-on 
• 111869-44-4 7-(2,3-Didesoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-glycero-pentofuranosyl)-2-<(dimethylamino)methylenamino>-3,7-dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-on 
• 111869-42-2 7-<2-Desoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-2-<(dimethylamino)methylenamino>-3,7-dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-on 
• 111869-43-3 7-<2-Desoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-3-O-(phenoxythiocarbonyl)-β-D-erythro-pentofuranosyl>-2-<(dimethylamino)methylenamino>-3,7-dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-on 
• 111869-46-6 7-(2-Desoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl)-2-<(4,4'-dimethoxytriphenylmethyl)amino>-3,7-dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-on 
• 104291-17-0 2-amino-4-chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 123439-73-6 2-amino-4-chloro-7-<2,3-dideoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-glycero-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 123439-70-3 2-amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 123439-72-5 2-amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-3-O-(methoxythiocarbonyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 123439-71-4 Imidazole-1-carbothioic acid O-[(2R,3S,5R)-5-(2-amino-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl] ester 

Relevant articles and documents

Synthesis of 4-Substituted 2-Aminopyrrolopyrimidine 2',3'-Dideoxyribonucleosides

A number of new 2-aminopyrrolopyrimidine N-7-(2',3'-dideoxyribonucleosides) (11 - 13 and 15) were synthesized.These are related to 7-deaza-2',3'-dideoxyguanosine (14), but carry various substituents at C-4. 2-Amino-4-chloro-7-(2',3'-dideoxy-β-D-glycero-pentofuranosyl)-7H-pyrrolopyrimidine (3) was used as a common intermediate, and was obtained from the corrsponding 2'-deoxyribonucleoside 4 by selective silylation of 5'-OH and Barton deoxygenation of 3'-OH.