111888-13-2

Basic information

• Product Name: 2H-1-Benzopyran-2-one, 4-chloro-7-methoxy-3-phenyl-
• CAS NO: 111888-13-2
• Molecular Formula: C16H11ClO3
• Molecular Weight: 286.715
• Mol File: 111888-13-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-2-one, 4-chloro-7-methoxy-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 4-chloro-7-methoxy-3-phenyl-(111888-13-2)
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 4-chloro-7-methoxy-3-phenyl-(111888-13-2)

Safety Data

• Hazardous Substances Data: 111888-13-2(Hazardous Substances Data)

Upstream product

• 2555-24-0 4-hydroxy-7-methoxy-3-phenylcoumarin 

Relevant articles and documents

3-phenylcoumarins as inhibitors of HIV-1 replication

We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Six compounds displayed NF-κB inhibition, four resulted Tat antagonists and three of them showed both activities. Three compounds inhibited HIV replication with IC50 values 25 μM. The antiviral effect of the 4-hydroxycoumarin derivative 19 correlates with its specific inhibition of Tat functions, while compound 8, 3-(2-chlorophenyl) coumarin, seems to act through a mechanism unrelated to the molecular targets considered in this research.