2555-24-0Relevant articles and documents
3-phenylcoumarins as inhibitors of HIV-1 replication
Olmedo, Dionisio,Sancho, Rocio,Bedoya, Luis M.,Lopez-Perez, Jose L.,Del Olmo, Esther,Munoz, Eduardo,Alcami, Jose,Gupta, Mahabir P.,Feliciano, Arturo San
, p. 9245 - 9257 (2013/01/14)
We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Six compounds displayed NF-κB inhibition, four resulted Tat antagonists and three of them showed both activities. Three compounds inhibited HIV replication with IC50 values 25 μM. The antiviral effect of the 4-hydroxycoumarin derivative 19 correlates with its specific inhibition of Tat functions, while compound 8, 3-(2-chlorophenyl) coumarin, seems to act through a mechanism unrelated to the molecular targets considered in this research.
Phase transfer catalyst mediated one-pot synthesis of 4-hydroxy-3- phenylcoumarin
Sripathi, Shubashini K.,Sivakamasundari
, p. 789 - 790 (2007/10/03)
The synthesis of two new 3-aryl-4-hydroxycoumarins under phase transfer catalyst conditions is described.
The chemistry of pentavalent organobismuth reagents. Part XII. Synthesis of isoflavanones and 3-aryl-4-hydroxycoumarins
Barton,Donnelly,Finet,Stenson
, p. 6387 - 6396 (2007/10/02)
-