112020-13-0Relevant articles and documents
Tandem reactions of anions: A short and efficient route to ±anatoxin-a
Parsons, Philip J.,Camp, Nicholas P.,Underwood, J. Mark,Harvey, Darren M.
, p. 11637 - 11642 (1996)
A new route to anatoxin-a (1) is reported which involves an anionically induced small ring opening/ring closure/ring opening cascade. The azabicyclo [4.2.1]nonane ring system of anatoxin-α is hence formed in one synthetic operation.
PdII-Mediated Oxidative Amination for Access to a 9-Azabicyclo[4.2.1]nonane Compound Library and Anatoxin-a
Dawood, Rafid S.,Chidipudi, Suresh R.,O'Connor, Daniel C.,Lewis, William,Hamza, Daniel,Pearce, Christopher A.,Jones, Geraint,Wilkie, Ross P.,Georgiou, Irene,Storr, Thomas E.,Moore, Jonathan C.,Stockman, Robert A.
, p. 5558 - 5561 (2018/10/26)
Intramolecular oxidative amination of readily accessible aminocyclooct-4-enes provides rapid and regioselective access to the 9-azabicyclo[4.2.1]nonane framework characteristic of the natural product anatoxin-a (1). This has enabled the synthesis of sp3-rich chemical scaffolds suitable for diversification. A library of 881 lead-like compounds is reported alongside a formal synthesis of anatoxin-a (1).
Synthetic and Stereochemical Studies Directed Towards Anatoxin-a
Huby, Nicholas J. S.,Kinsman, Richard G.,Lathbury, David,Vernon, Peter G.,Gallagher, Timothy
, p. 145 - 155 (2007/10/02)
The synthesis and stereocontrolled Ag1-catalysed cyclisation of a series of allenic amino esters 8a-e is described.For compounds 8a-d the cis-2,5-disubstituted pyrrolidine 9 is formed exclusively but the primary amine 8e undergoes cyclisation n