112398-75-1

Basic information

• Product Name: 5-CHLORO-1-METHYLINDOLE
• Synonyms: 5-CHLORO-1-METHYLINDOLE;5-chloro-1-methyl-1H-indole
• CAS NO: 112398-75-1
• Molecular Formula: C₉H₈ClN
• Molecular Weight: 165.62
• Mol File: 112398-75-1.mol
• Article Data: 60

Chemical Properties

• Melting Point: 35 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 278.4±13.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 5-CHLORO-1-METHYLINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-1-METHYLINDOLE(112398-75-1)
• EPA Substance Registry System: 5-CHLORO-1-METHYLINDOLE(112398-75-1)

Safety Data

• Hazardous Substances Data: 112398-75-1(Hazardous Substances Data)

Usage

General Description

5-CHLORO-1-METHYLINDOLE is a chemical compound with the molecular formula C9H8ClN. It is an organic compound that belongs to the indole class of chemicals, which are commonly found in plants and animals. This specific compound is a derivative of indole, with a chlorine atom attached to the fifth carbon and a methyl group attached to the first carbon. It is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its properties and uses make it an important building block in the production of a wide range of chemical products.

Upstream product

• 17422-32-1 5-chloro-1H-indole 
• 74-88-4 methyl iodide 
• 181651-29-6 N-(4-chlorophenyl)-N-methylethenesulfinamide 
• 210536-18-8 (4-Chloro-2-vinyl-phenyl)-methyl-amine 
• 932-96-7 N-methyl(p-chloroaniline) 
• 210536-10-0 N-(4-Chloro-2-vinyl-phenyl)-2,2,2-trifluoro-N-methyl-acetamide 
• 1352621-91-0 1-bromo-2-(4-chlorophenylamino)ethanesulfonic acid 2,4,6-trichlorophenyl ester 
• 1352622-03-7 1-bromo-2-[(4-chlorophenyl)methylamino]ethanesulfonic acid 2,4,6-trichlorophenyl ester 
• 616-38-6 carbonic acid dimethyl ester 
• 26663-50-3 5-chloro-1-methylindoline 
• 32617-55-3 5-chloro-1-p-toluenesulfonylindole 
• 865-33-8 potassium methanolate 
• 25658-80-4 5-chloro-2,3-dihydroindole 
• 10075-50-0 5-bromo-1H-indole 

Downstream Products

• 186129-25-9 1-methyl-1H-indole-5-carboxylic acid 
• 1018914-02-7 5-chloro-1-methyl-2-phenyl-1H-indole 
• 1273594-89-0 5-chloro-3-dimethylphenylsilyl-1-methylindole 
• 441715-86-2 C₃₁H₃₃ClFN₃O₅ 
• 441712-68-1 trans-4-[1-[[2-(5-chloro-1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid 
• 1356053-19-4 C₂₄H₁₉ClN₂O 
• 1422273-98-0 (5-chloro-1-methyl-1H-indol-3-yl)(phenyl)methanone 
• 1440662-94-1 (E)-3-(5-chloro-1-methyl-1H-indol-3-yl)-1-phenylprop-2-en-1-one 
• 1579298-93-3 N-(5-chloro-1-methyl-3-(4-nitrophenylimino)indolin-2-ylidene)-4-nitrobenzenamine 
• 837392-62-8 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 
• 1607841-66-6 1-methyl-5-(4-methylphenyl)indole 

Relevant articles and documents

Regioselective 2-alkylation of indoles with α-bromo esters catalyzed by Pd/P,P=O system

A palladium-catalyzed 2-alkylation of indoles with α-bromo esters is developed by employing a P,P=O ligand. The method features excellent regioselectivities, mild reaction conditions, and good functional group compatibility. The employment of the P,P=O ligand as well as 4? molecular sieves were crucial for the success of the transformation. Mechanistic studies indicate the reaction proceed through a radical pathway.

Copper-Catalyzed Synthesis of Indolyl Benzo[b]carbazoles and Their Photoluminescence Property

A copper-catalyzed cascade cyclization of dihydroisobenzofurans with indoles for the rapid construction of indoly benzo[b]carbazoles has been reported, providing the desired products in moderate to good yields under mild conditions along with a broad substrate scope and good functional group tolerance. The photoluminescence property of these indoly benzo[b]carbazoles has also been investigated.

Tandem iridium-catalyzed decarbonylative c-h activation of indole: Sacrificial electron-rich ketone-assisted bis-arylsulfenylation

Described herein is a decarbonylative tandem C-H bis-arylsulfenylation of indole at the C2 and C4 C-H bonds through the use of pentamethylcyclopentadienyl iridium dichloride dimer ([Cp?IrCl2]2) catalyst and disulfides. A new sacrificial electron-rich adamantoyl-directing group facilitates indole C-H bis-functionalization with a traceless in situ removal. Various differently substituted disulfides can be easily accommodated in this reaction by a coordination to Ir(III) through the formation of six- and five-membered iridacycles at the C2 and C4 positions, respectively. Mechanistic studies show that a C-H activation-induced C-C activation is involved in the catalytic cycle.