1125576-35-3

Basic information

• Product Name: (R)-N-(1-(4-methoxyphenyl)ethyl)-4-methyl-benzenesulfonamide
• Synonyms: (R)-N-(1-(4-methoxyphenyl)ethyl)-4-methyl-benzenesulfonamide
• CAS NO: 1125576-35-3
• Molecular Weight: 305.398
• Mol File: 1125576-35-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (R)-N-(1-(4-methoxyphenyl)ethyl)-4-methyl-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(1-(4-methoxyphenyl)ethyl)-4-methyl-benzenesulfonamide(1125576-35-3)
• EPA Substance Registry System: (R)-N-(1-(4-methoxyphenyl)ethyl)-4-methyl-benzenesulfonamide(1125576-35-3)

Safety Data

• Hazardous Substances Data: 1125576-35-3(Hazardous Substances Data)

Upstream product

• 6298-96-0 1(R)-(4-methoxyphenyl)-ethylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 70-55-3 toluene-4-sulfonamide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 941-55-9 4-toluenesulfonyl azide 
• 1515-95-3 p-ethylanisole 
• 842120-96-1 N-[1-(4-methoxyphenyl)-ethylidene]-4-methyl-benzenesulfonamide 
• 127-65-1 chloroamine-T 

Downstream Products

• 97637-73-5 N-[1-(4-methoxyphenyl)ethyl]-p-toluenesulfonamide 
• 865541-03-3 (R)-3-(4-methoxyphenyl)-1-phenylbutan-1-one 
• 87258-61-5 (S)-(+)-3-p-methoxyphenyl-1-phenylbutan-1-one 
• 129919-76-2 3-(4-methoxyphenyl)-1,3-diphenyl-1-propanone 
• 107270-96-2 1-(1-Benzenesulfonyl-ethyl)-4-methoxy-benzene 

Relevant articles and documents

Nickel-Catalyzed Asymmetric Transfer Hydrogenation and α-Selective Deuteration of N-Sulfonyl Imines with Alcohols: Access to α-Deuterated Chiral Amines

A nickel-catalyzed enantioselective transfer hydrogenation and deuteration of N-sulfonyl imines was developed. Excellent α-selectivity and high deuterium content were achieved by using inexpensive 2-propanol-d8 as a deuterium source. As a highlight, no deuteration of β-C-H and the remote C-H of N-sulfonyl amines occurred, which is hard to achieve using other imines or by hydrogen isotope exchange with D2O. Mechanism studies indicated a stepwise pathway through the [Ni-D] intermediate.

Enantioselective, intermolecular benzylic C-H amination catalysed by an engineered iron-haem enzyme

C-H bonds are ubiquitous structural units of organic molecules. Although these bonds are generally considered to be chemically inert, the recent emergence of methods for C-H functionalization promises to transform the way synthetic chemistry is performed. The intermolecular amination of C-H bonds represents a particularly desirable and challenging transformation for which no efficient, highly selective, and renewable catalysts exist. Here we report the directed evolution of an iron-containing enzymatic catalyst - based on a cytochrome P450 monooxygenase - for the highly enantioselective intermolecular amination of benzylic C-H bonds. The biocatalyst is capable of up to 1,300 turnovers, exhibits excellent enantioselectivities, and provides access to valuable benzylic amines. Iron complexes are generally poor catalysts for C-H amination: in this catalyst, the enzyme's protein framework confers activity on an otherwise unreactive iron-haem cofactor.

Catalytic coupling of N-benzylic sulfonamides with silylated nucleophiles at room temperature

In the presence of 2-10 mol% of Tf2NH, a range of N-benzylic sulfonamides smoothly react with allylic, propargylic, benzylic, or hydrido silanes at room temperature via sp3 carbon-nitrogen bond cleavage to afford structurally diverse products in moderate to excellent yields and with high chemo- and regioselectivity.