112698-06-3

Basic information

• Product Name: 2-Butanone,4-(2-ethoxytetrahydro-2H-pyran-3-yl)-,cis-(9CI)
• Synonyms: 2-Butanone,4-(2-ethoxytetrahydro-2H-pyran-3-yl)-,cis-(9CI)
• CAS NO: 112698-06-3
• Molecular Formula: C₁₁H₂₀O₃
• Molecular Weight: 200.27
• Product Categories: ETHOXY
• Mol File: 112698-06-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Butanone,4-(2-ethoxytetrahydro-2H-pyran-3-yl)-,cis-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone,4-(2-ethoxytetrahydro-2H-pyran-3-yl)-,cis-(9CI)(112698-06-3)
• EPA Substance Registry System: 2-Butanone,4-(2-ethoxytetrahydro-2H-pyran-3-yl)-,cis-(9CI)(112698-06-3)

Safety Data

• Hazardous Substances Data: 112698-06-3(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 64-17-5 ethanol 
• 78-94-4 methyl vinyl ketone 
• 881421-26-7 (Z)-3-Ethoxy-but-2-en-1-ol 
• 67935-24-4 (E)-3-ethoxybut-2-en-1-ol 

Downstream Products

• 112698-15-4 Octahydro-chromen-7-one 

Relevant articles and documents

2-Alkoxy-3-oxoalkyl-tetrahydropyrans and -tetrahydrofurans: versatile intermediates in heterocyclic synthesis

A new Lewis acid-catalysed Michael-type addition of heterocyclic enol ethers to hemiacetal vinylogues 1 or to enones in the presence of a hydroxylic compounds is described.The 1,5-keto acetal 3 so obtained have been studied with a view to synthetic applications.Acidic hydrolysis of compound 3 leads in most cases to annulation products 9 in a stereocontrolled manner.Organometallic addition, hydride reduction or reductive amination of 1,5-keto acetals 3 afford, in good yields, the hydroxy acetals 12 (and cyclisation products 13) and amino acetals 18, respectively.Acidic treatment of these compounds gave access to oxa- and aza-annulation products 13, 17 and 19 by an efficient kinetically controlled heterocyclisation process.These products can be obtained with high cis-junction selectivities as established by NMR spectroscopy and confirmed by equilibration studies.