1128-85-4

Basic information

• Product Name: 3-Amino-1-phenyl-2-buten-1-one
• Synonyms: 3-Amino-1-phenyl-2-buten-1-one
• CAS NO: 1128-85-4
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Mol File: 1128-85-4.mol
• Article Data: 18

Chemical Properties

• Melting Point: 60-62 °C(Solv: chloroform (67-66-3))
• Boiling Point: 264.2°C at 760 mmHg
• Flash Point: 113.6°C
• Appearance: /
• Density: 1.067g/cm³
• Vapor Pressure: 0.00984mmHg at 25°C
• Refractive Index: 1.561
• PKA: 5.62±0.70(Predicted)
• CAS DataBase Reference: 3-Amino-1-phenyl-2-buten-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-1-phenyl-2-buten-1-one(1128-85-4)
• EPA Substance Registry System: 3-Amino-1-phenyl-2-buten-1-one(1128-85-4)

Safety Data

• Hazardous Substances Data: 1128-85-4(Hazardous Substances Data)

Usage

General Description

3-Amino-1-phenyl-2-buten-1-one, also known as 3-APB, is an organic compound with the chemical formula C10H11NO. It is a yellow solid that is commonly used as a precursor in the synthesis of pharmaceuticals and other organic compounds. 3-APB is an important intermediate in the production of various drugs and is also used in research and development. It is known for its ability to form a variety of chemical bonds and is used in the manufacture of a wide range of compounds. Additionally, it is also used in the production of perfumes and is a valuable chemical in the field of organic chemistry.

InChI:InChI=1/C10H11NO/c1-8(11)7-10(12)9-5-3-2-4-6-9/h2-7H,11H2,1H3

Upstream product

• 1008-75-9 3-methyl-5-phenylisoxazole 
• 57-13-6 urea 
• 93-91-4 1-phenylbutan-1,3-dione 
• 100-52-7 benzaldehyde 
• 7664-41-7 ammonia 
• 98-86-2 acetophenone 
• 1336-21-6 ammonium hydroxide 
• 120-46-7 1,3-diphenylpropanedione 

Downstream Products

• 1226-92-2 1-phenyl-3-benzoylamino-2-buten-1-one 
• 23652-96-2 N-(1-methyl-3-oxo-3-phenyl-propenyl)-acetamide 
• 5220-61-1 (2-methylpyridin-3-yl)(phenyl)methanone 
• 16232-41-0 2-hydroxy-6-methyl-4-phenyl-nicotinonitrile 
• 35929-88-5 3-benzoyl-2-methyl-4-phenyl-1,4-dihydro-indeno[1,2-b]pyridin-5-one 
• 4240-97-5 2-hydroxy-4-methyl-6-phenyl-nicotinonitrile 
• 27337-94-6 1,4-dimethyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile 
• 260247-89-0 (2-methyl-5,6,7,8-tetrahydroquinolin-3-yl)(phenyl)methanone 
• 28994-53-8 2-ethoxy-2,4-dimethyl-6-phenyl-2H-[1,3]oxazine 
• 63205-26-5 3-(Trichloracetamido)-1-phenyl-2-buten-1-on 
• 140706-32-7 3,7-diphenyl-2-hydroxy-5-methylpyrazolo<1,5-a>pyrimidine 
• 22192-06-9 3-benzoyl-2,6-dimethyl-4(1H)-pyridone 
• 113123-52-7 3-benzoyl-4-methyl-6-phenyl-2(1H)-pyridone 
• 102252-88-0 5-benzoyl-6-methyl-2(1H)-pyridinone 

Relevant articles and documents

Metal-Free Synthesis of Fully Substituted Pyridines via Ring Construction Based on the Domino Reactions of Enaminones and Aldehydes

An unprecedented domino reaction involving primary enaminones/enaminoesters and aldehydes has been developed for the synthesis of fully substituted pyridines. The construction of the products has been accomplished via the cascade generation of two C-C and

Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators

Free fatty acid receptor 3 (FFA3, previously GPR41) is activated by short-chain fatty acids, mediates health effects of the gut microbiota, and is a therapeutic target for metabolic and inflammatory diseases. The shortage of well-characterized tool compounds has however impeded progress. Herein, we report structure-activity relationship of an allosteric modulator series and characterization of physicochemical and pharmacokinetic properties of selected compounds, including previous and new tools. Two representatives, 57 (TUG-1907) and 63 (TUG-2015), showed improved solubility and preserved potency. Of these, 57, with EC50 = 145 nM and a solubility of 33 μM, showed high clearance in vivo but is a preferred tool in vitro. In contrast, 63, with EC50 = 162 nM and a solubility of 9 μM, showed lower clearance and seems better suited for in vivo studies. Using 57, we demonstrate for the first time that FFA3 activation leads to calcium mobilization in murine dorsal root ganglia.

Β-carbonyl enamines compound and as the application of the preparation of plant pathogenic bacteria antibacterial agent (by machine translation)

The invention relates to a β-carbonyl compound and enamines preparation of plant pathogenic bacteria as the application of an antimicrobial agent. Commercially available antibacterial agent Mijunzhi as a positive control, the linear growth of the mycelium determination process 23 kind of target compound anthrax pathogenicbacteria the apple, corn curved spore pathogenic bacterium, pathogenic bacteria rice blast fungus, reducing bakanae disease of wheat, such as watermelon blighting pathogenicbacteria 5 common inhibiting activity of plant pathogenic fungi, the result shows that: the target compound has tries the fungus inhibiting effect of different degree. Compound 8, 11, 12, 14, 16 of the activity is better, for the majority of their pathogenic bacteria testing EC 50 half of the effect of the concentration value is higher than the positive control drug kresoxim-methyl. Especially compound 8 inhibition of anthrax pathogenicbacteria the apple active (EC 50 = 2.15μg/mL) compound and 12 the inhibitory activity of pathogenic bacterium curved spore (EC 50 = 9.14μg/mL) are Mijunzhi active (EC 50 = 15.45 & 76.06μg/mL) of 8 times, has potential development and application values. (by machine translation)