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1128103-55-8

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1128103-55-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1128103-55-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,2,8,1,0 and 3 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1128103-55:
(9*1)+(8*1)+(7*2)+(6*8)+(5*1)+(4*0)+(3*3)+(2*5)+(1*5)=108
108 % 10 = 8
So 1128103-55-8 is a valid CAS Registry Number.

1128103-55-8Relevant articles and documents

Discovery of a potent pyrazolopyridine series of γ-secretase modulators

Qin, Jun,Zhou, Wei,Huang, Xianhai,Dhondi, Pawan,Palani, Anandan,Aslanian, Robert,Zhu, Zhaoning,Greenlee, William,Cohen-Williams, Mary,Jones, Nicholas,Hyde, Lynn,Zhang, Lili

, p. 471 - 476 (2011/08/22)

The synthesis and structure-activity relationship of a novel series of pyrazolopyridines are reported. These compounds represent a new class of γ-secretase modulators that demonstrate good in vitro potency in inhibiting Aβ42 production. Example

GAMMA SECRETASE MODULATORS

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Page/Page column 170-171, (2009/07/17)

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).

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