403-41-8

Basic information

• Product Name: 1-(4-Fluorophenyl)ethanol
• Synonyms: 4-fluoro-α-methylbenzyl alcohol;4-Fluoro-alpha-methylbenzyl alcohol 97%;4-Fluoro-alpha-methylbenzylalcohol97%;1-(p-Fluorophenyl)ethyl alcohol;4-Fluoro-α-methylbenzenemethanol;α-Methyl-4-fluorobenzenemethanol;α-Methyl-4-fluorobenzyl alcohol;4-Fluoro-alpha-methylbenzyl alcohol,99%
• CAS NO: 403-41-8
• Molecular Formula: C₈H₉FO
• Molecular Weight: 140.15
• EINECS: 206-959-3
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Fluorine Compounds;Phenols;Alcohols;C7 to C8;Oxygen Compounds;Fluorine series
• Mol File: 403-41-8.mol
• Article Data: 507

Chemical Properties

• Melting Point: 9 °C
• Boiling Point: 90-92 °C7 mm Hg(lit.)
• Flash Point: 195 °F
• Appearance: clear light yellow liquid
• Density: 1.109 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0829mmHg at 25°C
• Refractive Index: n20/D 1.501(lit.)
• Storage Temp.: 2-8°C
• PKA: 14.36±0.20(Predicted)
• CAS DataBase Reference: 1-(4-Fluorophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenyl)ethanol(403-41-8)
• EPA Substance Registry System: 1-(4-Fluorophenyl)ethanol(403-41-8)

Safety Data

• Hazard Codes: Xi,F,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 403-41-8(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow liquid

General Description

4-Fluoro-α-methylbenzyl alcohol was isolated as phytocomponent in the methanolic extracts of the whole plant of Thevetia peruviana.

InChI:InChI=1/C8H9FO/c1-6(10)7-2-4-8(9)5-3-7/h2-6,10H,1H3

Upstream product

• 917-64-6 methyl magnesium iodide 
• 459-57-4 4-fluorobenzaldehyde 
• 75-16-1 methylmagnesium bromide 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 75-07-0 acetaldehyde 
• 352-13-6 4-flourophenylmagnesium bromide 
• 456-16-6 1-(1-chloroethyl)-4-fluorobenzene 
• 67-56-1 methanol 
• 75-89-8 2,2,2-trifluoroethanol 
• 405-99-2 para-fluorostyrene 
• 107-03-9 1-thiopropane 
• 64-17-5 ethanol 
• 598-38-9 2,2-dicloroethanol 
• 127-09-3 sodium acetate 

Downstream Products

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 15954-42-4 1.1-Dichlor-3--buten-(1) 
• 456-16-6 1-(1-chloroethyl)-4-fluorobenzene 
• 2063-74-3 4,4'-(1,1'-oxybis(ethane-1,1-diyl))bis(fluorobenzene) 
• 65130-46-3 1-(4-fluorophenyl)ethyl bromide 
• 127036-05-9 <1-(4-fluorophenyl)ethyl>triphenylphosphonium bromide 
• 111662-72-7 1-(4-fluorophenyl)ethyl methyl ether 
• 959043-40-4 6-[1-(4-Fluoro-phenyl)-ethyl]-benzo[1,3]dioxol-5-ol 
• 111662-74-9 1-(4-fluorophenyl)ethyl ethyl ether 
• 31067-69-3 (p-fluorophenyl)methylcarbenium ion 
• 117768-34-0 1-(4-fluorophenyl)ethyl vinyl ether 
• 403-31-6 4-fluoro-2-hydroxy-acetophenone 
• 169301-03-5 2-Nitro-benzoic acid 1-(4-fluoro-phenyl)-ethyl ester 
• 172585-57-8 (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester 

Relevant articles and documents

N-Propylphthalimide-Substituted Silver(I) N-Heterocyclic Carbene Complexes and Ruthenium(II) N-Heterocyclic Carbene Complexes: Synthesis and Transfer Hydrogenation of Ketones

This study deals with the synthesis of N-propylphthalimide substituted Ag(I)-N-heterocyclic carbene (NHC) complexes and N-propylphthalimide substituted Ru(II)-NHC complexes in the transfer hydrogenation of ketones. The Ag(I)-NHC complexes were synthesized

Ru(ii)-N-heterocyclic carbene complexes: Synthesis, characterization, transfer hydrogenation reactions and biological determination

A series of ruthenium(ii) complexes with N-heterocyclic carbene ligands were successfully synthesized by transmetalation reactions between silver(i) N-heterocyclic carbene complexes and [RuCl2(p-cymene)]2 in dichloromethane under Ar

Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones

Most ligands applied for asymmetric hydrogenation are synthesized via multistep reactions with expensive chemical reagents. Herein, a series of novel and easily accessed cinchona-alkaloid-based NNP ligands have been developed in two steps. By combining [Ir(COD)Cl]2, 39 ketones including aromatic, heteroaryl, and alkyl ketones have been hydrogenated, all affording valuable chiral alcohols with 96.0-99.9% ee. A plausible reaction mechanism was discussed by NMR, HRMS, and DFT, and an activating model involving trihydride was verified.

Tridentate nitrogen phosphine ligand containing arylamine NH as well as preparation method and application thereof

The invention discloses a tridentate nitrogen phosphine ligand containing arylamine NH as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The tridentate nitrogen phosphine ligand disclosed by the invention is the first case of tridentate nitrogen phosphine ligand containing not only a quinoline amine structure but also chiral ferrocene at present, a noble metal complex of the type of ligand shows good selectivity and extremely high catalytic activity in an asymmetric hydrogenation reaction, meanwhile, a cheap metal complex of the ligand can also show good selectivity and catalytic activity in the asymmetric hydrogenation reaction, and is very easy to modify in the aspects of electronic effect and space structure, so that the ligand has huge potential application value. A catalyst formed by the ligand and a transition metal complex can be used for catalyzing various reactions, can be used for synthesizing various drugs, and has important industrial application value.