1128105-72-5Relevant articles and documents
Discovery of a potent pyrazolopyridine series of γ-secretase modulators
Qin, Jun,Zhou, Wei,Huang, Xianhai,Dhondi, Pawan,Palani, Anandan,Aslanian, Robert,Zhu, Zhaoning,Greenlee, William,Cohen-Williams, Mary,Jones, Nicholas,Hyde, Lynn,Zhang, Lili
, p. 471 - 476 (2011/08/22)
The synthesis and structure-activity relationship of a novel series of pyrazolopyridines are reported. These compounds represent a new class of γ-secretase modulators that demonstrate good in vitro potency in inhibiting Aβ42 production. Example
GAMMA SECRETASE MODULATORS
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Page/Page column 434, (2009/04/25)
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formul