112823-30-0

Basic information

• Product Name: 3-(iodomethyl)-3-methyloxetane
• Synonyms: 3-(iodomethyl)-3-methyloxetane;3-(iodoomethyl)-3-methyloxetane;3-(iodoMethyl)-3-Methylox...;3-(IodoMethyl)-3-Methyloxetane Oxetane, 3-(iodoMethyl)-3-Methyl-;Oxetane,3-(iodomethyl)-3-methyl-
• CAS NO: 112823-30-0
• Molecular Formula: C₅H₉IO
• Molecular Weight: 212.03
• Mol File: 112823-30-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 187.696 °C at 760 mmHg
• Flash Point: 67.316 °C
• Appearance: /
• Density: 1.762 g/cm³
• CAS DataBase Reference: 3-(iodomethyl)-3-methyloxetane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(iodomethyl)-3-methyloxetane(112823-30-0)
• EPA Substance Registry System: 3-(iodomethyl)-3-methyloxetane(112823-30-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 112823-30-0(Hazardous Substances Data)

Usage

General Description

3-(iodomethyl)-3-methyloxetane is a compound that belongs to the class of organohalogen compounds. It is composed of a 3-methyloxetane ring with an iodomethyl group attached to one of its carbons. 3-(iodomethyl)-3-methyloxetane is primarily used in organic synthesis and chemical research as a reagent and building block for the production of various organic compounds.

Upstream product

• 99314-44-0 (3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate 
• 822-48-0 3-chloromethyl-3-methyl oxetane 
• 3143-02-0 3-hydroxymethyl-3-methyloxethane 

Downstream Products

• 497870-41-4 2-(3-methyloxetan-3-ylmethoxymethyl)-2-phenyl-1,3-dioxolane 
• 497870-42-5 2-(3-methyloxetan-3-ylmethoxy)-1-phenylethanone 
• 497870-44-7 3-(3-methyloxetan-3-ylmethoxy)-1-phenylpropan-1-one 
• 1469979-79-0 (rac)-7-((3-methyloxetan-3-yl)methoxy)-4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridine 
• 3753-52-4 3-methyl-3-p-tolyloxymethyl-oxetane 

Relevant articles and documents

Facile synthesis, macroscopic separation, E/Z isomerization, and distinct AIE properties of pure stereoisomers of an oxetane-substituted tetraphenylethene luminogen

Control of stereochemistry plays a key role in medicinal chemistry, material and life science. As a prominent AIE luminogen, tetraphenylethene (TPE) derivatives have E/Z isomers which are challenging to separate even by HPLC. Herein, we designed oxetane-substituted TPE (TPE-2OXE) and separated pure isomers by simple column chromatography with high yields, as confirmed by mass spectrometry, IR and NMR spectroscopy. The isomerization of the two isomers can occur by photo- and thermo-activation. Importantly, (Z)-TPE-2OXE isomer solid shows bathochromic emission with a quantum yield 5 times higher than that of (E)-TPE-2OXE. The differences in emission wavelength and quantum yield are derived from distinct emission mechanisms of locally excited (LE) state emission of (E)-TPE-2OXE and charge transfer (CT) state emission of (Z)-TPE-2OXE. The two isomers are also good piezochromic luminescent materials, which have not only an obvious emission color shift but also significantly enhanced luminescence brightness by external force. In addition, (E)-TPE-2OXE solids show self-healing ability, which can crystallize spontaneously from ground amorphous state. The higher brightness of (E)-TPE-2OXE can be retained in solution, so fluorescent AIE nanodots are prepared from the two isomers. Cell-labeling experiments also show that (Z)-TPE-2OXE AIE dots have higher labeling brightness as compared to the (E)-TPE-2OXE isomer. The synthesis and distinct properties of E/Z isomers are beneficial to further development of new TPE derivatives for various applications.

Novel pyrrolopyridine derivatives and its use as HIV inhibitor

The present invention relates to a pyrrolopyridine derivative expressed as chemical formula 1, specifically a compound including a substituent group having an oxatane group in R1, its stereoisomer or racemic body, their pharmaceutically acceptable salts or their solvate, a manufacturing method thereof, and an antivirus composition containing the same as an active ingredient, wherein the compound expressed as chemical formula 1 has excellent selectivity and physiological activity with respect to wild type or resistant HIV-1 and therefore can be used as a remedy for AIDS.

PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A and n are as described herein, compositions including the compounds and methods of using the compounds.