113534-13-7

Basic information

• Product Name: 2-Propanol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)- (9CI)
• Synonyms: 2-Propanol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)- (9CI);(2S)-1-{[(1,1-Dimethylethyl)dimethylsilyl]-oxy}-2-propanol
• CAS NO: 113534-13-7
• Molecular Formula: C₉H₂₂O₂Si
• Molecular Weight: 190.36
• Mol File: 113534-13-7.mol
• Article Data: 33

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propanol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)- (9CI)(113534-13-7)
• EPA Substance Registry System: 2-Propanol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)- (9CI)(113534-13-7)

Safety Data

• Hazardous Substances Data: 113534-13-7(Hazardous Substances Data)

Usage

General Description

2-Propanol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)- (9CI) is a chemical compound with the molecular formula C8H20OSi. It is also known as (S)-1-tert-Butyldimethylsilyloxypropan-2-ol and is commonly used as a protecting reagent in organic synthesis. 2-Propanol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)- (9CI) has a chiral center and exists as a pair of enantiomers, with the (2S)-enantiomer being the one specified in the chemical name. It is a colorless liquid with a slightly sweet odor, and it is flammable and volatile. 2-Propanol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)- (9CI) is primarily used in laboratory settings for chemical reactions that require protection of specific functional groups. Its use in the pharmaceutical industry and in biotechnology research is also important in the synthesis of various drugs and compounds.

Upstream product

• 4254-15-3 (S)-1,2-Propanediol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 87681-24-1 methyl (S)-2-(tert-butyldimethylsiloxy)propanoate 
• 113534-13-7 1-{[tert-butyl(dimethyl)silyl]oxy}propan-2-ol 
• 57-55-6 propylene glycol 
• 29681-57-0 tert-butyldimethylsilane 
• 119404-55-6 2-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester 
• 4254-14-2 (2R)-propane-1,2-diol 

Downstream Products

• 113534-14-8 (S)-1-(tert-butyldimethylsiloxy)-2-(benzoyloxy)propane 
• 74685-00-0 1-(tert-butyldimethylsiloxy)-2-propanone 
• 128733-25-5 Benzoic acid 2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl ester 
• 870104-82-8 (2S)-1-{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-propanol (R)-α-methoxyphenylacetic acid ester 
• 870104-83-9 (2S)-1-{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-propanol (S)-α-methoxyphenylacetic acid ester 
• 763110-32-3 [(1R)-1-methyl-2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl](2,5-difluorpohenyl)[(5-chloro-2-thienyl)sulfonyl]amine 
• 174770-72-0 1-(tert-butyldimethylsilyloxy)-2(R)-[3-(4,5-dihydro-4(R)-phenyloxazol-2-yl)phenoxy]propane 
• 290328-14-2 C₂₁H₂₈Cl₃NO₃SSi 
• 1171817-09-6 C₂₄H₃₄O₅SSi 
• 1352444-31-5 tert-butyl(2-((4-methoxybenzyl)oxy)propoxy)dimethylsilane 
• 136918-07-5 (2R)-1[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-propanol 

Relevant articles and documents

The Utility of t-Butyldimethylsilane as an Effective Silylation Reagent for the Protection of Functional Groups

Treatment of compounds containing functional groups, such as alcohols, amines, and carboxylic acids, with t-butyldimethylsilane in the presence of a catalytic amount of palladium on carbon is described to provide a new, convenient method for the introduction of a t-butyldimethylsilyl (TBDMS) group.

Synthesis of 2-C-Methyl-D-erythritol 4-phosphate: The first pathway-specific intermediate in the methylerythritol phosphate route to isoprenoids

(matrix presented) 2-C-Methyl-D-erythritol 4-phosphate (4), formed from 1-deoxy-D-xylulose 5-phosphate (3), is the first pathway-specific intermediate in the methylerythritol phosphate route for the biosynthesis of isoprenoid compounds in bacteria, algae, and plant chloroplasts. In this report, 4 was synthesized from 1,2-propanediol (7) in seven steps with an overall yield of 32% and in an enantiomeric excess of 78%.

NAPHTHYRIDINE COMPOUNDS AS INHIBITORS OF MER TYROSINE KINASE AND AXL TYROSINE KINASE

The present invention relates to compounds of Formula (I) that function as inhibitors of MerTK activity, to processes for the preparation of such compounds, to pharmaceutical compositions comprising them and to their use in the treatment of proliferative

Using DMF as Both a Catalyst and Cosolvent for the Regioselective Silylation of Polyols and Diols

Highly regioselective silylation of primary hydroxyl groups of unprotected polyols and diols was obtained by the use of a mixed solvent of MeCN/DMF (10:1) in this study. DMF was discovered to be a good catalyst in this reaction, although the silylation us