1137486-76-0Relevant articles and documents
Synthesis and characterization of amino-NHC coinage metal complexes and application for C-H activation of caffeine
Huang, Hsuan-Jui,Lee, Wei-Chih,Yap, Glenn P.A.,Ong, Tiow-Gan
, p. 64 - 73 (2014/05/06)
This paper describes the synthesis and characterization of silver, copper and gold complexes supported by several amino-NHC ligands with different amino side arms. The transmetallation process using silver-NHC complexes can be used to prepare amino-NHC copper and gold complexes easily in high yield. In addition, the catalytic activities of copper complexes are examined for arylation of caffeine via C-H bond activation.
Palladium-catalyzed direct arylation of N-heteroarenes with arylsulfonyl hydrazides
Liu, Bo,Li, Jian,Song, Feijie,You, Jingsong
supporting information; experimental part, p. 10830 - 10833 (2012/09/22)
Hydrazides applied: A palladium-catalyzed direct Ci-H arylation of heteroarenes, with arylsulfonyl hydrazides as the arylating reagents, has been developed (see scheme). The reaction is chemoselective, in that arylsulfonyl hydrazides containing halogen substituents can be employed without participation of the halogen substituent in the reaction. The method offers a straightforward approach to a variety of aryl-heteroaryl compounds. Copyright
Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst
Zhao, Dongbing,Wang, Weida,Lian, Shuang,Yang, Fei,Lan, Jingbo,You, Jingsong
supporting information; experimental part, p. 1337 - 1340 (2009/09/04)
A new palladium-catalyzed methodology was developed for the direct C-arylation of azoles with a broad spectrum of aryl bromides without the presence of phosphines, the aid of CuI, or other metal additives by using pivalic acid as a cocatalyst. The method also allowed the direct C-arylation of the N-heterocycle N-oxides, and to a lesser degree, the perfluoroaromatics. It was also found that the method can not only be applied to the synthesis of 8-aryl-substituted caffeines, but also 8-arylated theophyllines and theobromines. The result showed thatthe method can tolerate an array of functional groups including ester, nitrile, nitro, aldehyde, methoxy, trifluoromethyl, fluoro, and chloro substituents, and can found its applications in a number of fields such as synthetic and medicinal chemistry both in industry and in academia.