114312-29-7

Basic information

• Product Name: (E)-1-(2,8-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate
• Synonyms: (E)-1-(2,8-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate
• CAS NO: 114312-29-7
• Molecular Weight: 664.66
• Mol File: 114312-29-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-(2,8-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2,8-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate(114312-29-7)
• EPA Substance Registry System: (E)-1-(2,8-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate(114312-29-7)

Safety Data

• Hazardous Substances Data: 114312-29-7(Hazardous Substances Data)

Upstream product

• 18903-01-0 trans-1-cinnamylpiperazine 
• 371-35-7 sodium 4-fluorophenoxide 
• 114312-63-9 2-<(4-Fluorophenyl)oxymethyl>-4-fluorobenzoic acid 
• 700-85-6 5-fluoroisobenzofuran-1(3H)-one 
• 114312-55-9 2,8-Difluoro-6,11-dihydrodibenzoxepin-11-one 

Relevant articles and documents

Synthesis and biological activity of 11-[4-(cinnamyl)-1-piperazinyl]-6,11-dihydrodibenz[b,e]oxepin derivatives, potential agents for the treatment of cerebrovascular disorders

A series of 11-[4-(cinnamyl)-1-piperazinyl]-6,11-dihydrodibenz[b,e]oxepins and related compounds were synthesized and evaluated for their protective activities against complete ischemia, normobaric hypoxia, lipidperoxidation and convulsion. Structure-activity relationship studies of this series led to the finding of (E)-1-(3-fluoro-6,11-dihydrodibenz[b,e]oxepin-11-yl)-4-(3-phenyl-2-prop enyl)piperazine dimaleate (50), AJ-3941 with the most appropriate property for combined pharmacological activities. Compound 50 also shows an inhibitory effect against cerebral edema as well when orally given to rats.