114469-22-6

Basic information

• Product Name: Nalpha-[2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-[4-(butylcarbamoyl)-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]histidinamide
• Synonyms: 1H-Imidazole-4-propanamide, N-[(1S,2S,4S)-4-[(butylamino)carbonyl]-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]-α-[[(2S)-2-[[(1,1-dimethylethyl)sulfonyl]methyl]-1-oxo-3-phenylpropyl]amino]-, (αS)-;1H-Imidazole-4-propanamide, N-(4-(butylamino)carbonyl)-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl)-alpha-((2-(((1,1-dimethylethyl)sulfonyl)methyl)-1-oxo-3-phenylpropyl)amino)-, (1S-(1R*(1R*(R*(R*)),2R*,4R*))-
• CAS NO: 114469-22-6
• Molecular Formula: C₃₉H₆₃N₅O₆S
• Molecular Weight: 730.0124
• Mol File: 114469-22-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 1019.7°C at 760 mmHg
• Flash Point: 570.5°C
• Density: 1.142g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: Nalpha-[2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-[4-(butylcarbamoyl)-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]histidinamide(CAS DataBase Reference)
• NIST Chemistry Reference: Nalpha-[2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-[4-(butylcarbamoyl)-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]histidinamide(114469-22-6)
• EPA Substance Registry System: Nalpha-[2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-[4-(butylcarbamoyl)-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl]histidinamide(114469-22-6)

Safety Data

• Hazardous Substances Data: 114469-22-6(Hazardous Substances Data)

Upstream product

• 14997-58-1 N-[(benzyloxy)carbonyl]-L-histidine 
• 74853-62-6 N^α,N^im-ditritylhistidine 
• 114469-35-1 3-<(benzyloxycarbonyl)amino>-4-cyclohexyl-1-iodo-2-<(trimethylsilyl)oxy>-(2R,3S)-butane 
• 105852-65-1 (2S)-2-[(4S,5S)-3-benzyloxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl]methyl-N-butyl-3-methylbutanamide 
• 105852-64-0 (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide 
• 105852-50-4 3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine 
• 556-24-1 methyl 3-methylbutanoate 
• 105852-62-8 (2S,4S,5S)-5-[(S)-2-Amino-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide 
• 114530-04-0 (S)-α-[[(1,1-dimethylethyl)-sulfonyl]methyl]benzenepropanoic acid 
• 105852-42-4 2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2S)-butyric acid 
• 114469-37-3 ((1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-iodo-propyl)-carbamic acid benzyl ester 
• 105852-63-9 [(S)-1-((1S,2S,4S)-4-Butylcarbamoyl-1-cyclohexylmethyl-2-hydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester 

Relevant articles and documents

Synthesis and biological activity of some transition-state inhibitors of human renin

A series of renin inhibitors containing the dipeptide transition state mimics (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-7-methyloctanoic acid (Leu-(OH)-Val) and (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-6-cyclohexylhexanoic acid (Cha-(OH)-Val) was prepared.