105852-64-0

Basic information

• Product Name: (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide
• Synonyms: (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide
• CAS NO: 105852-64-0
• Molecular Weight: 326.523
• Mol File: 105852-64-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide(105852-64-0)
• EPA Substance Registry System: (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide(105852-64-0)

Safety Data

• Hazardous Substances Data: 105852-64-0(Hazardous Substances Data)

Upstream product

• 124032-35-5 (2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide 
• 108-12-3 isopentanoyl chloride 
• 105852-42-4 (2RS)-2-[(4S,5S)-3-benzyloxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl]methyl-3-methylbutanoic acid 
• 503-74-2 3-methylbutyric acid 
• 124032-42-4 [(S)-2-Cyclohexyl-1-((S)-4-isopropyl-5-oxo-2,5-dihydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 124032-43-5 [(S)-2-Cyclohexyl-1-((R)-4-isopropyl-5-oxo-2,5-dihydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 124032-36-6 (3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one 
• 123580-22-3 [(S)-2-Cyclohexyl-1-((2S,4R)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 4522-04-7 ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalaninate 
• 169512-90-7 (S)-2-tert-Butoxycarbonylamino-3-cyclohexyl-propionic acid ethyl ester 
• 20201-24-5 ethyl 3-methyl-2-oxobutanoate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 105852-42-4 2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2S)-butyric acid 
• 114469-37-3 ((1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-iodo-propyl)-carbamic acid benzyl ester 

Downstream Products

• 114469-22-6 (2S,4S,5S)-5-[(S)-2-[(S)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide 
• 105852-62-8 (2S,4S,5S)-5-[(S)-2-Amino-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide 
• 105851-89-6 2,2-Dimethyl-propionic acid (S)-1-[(S)-1-((1S,2S,4S)-4-butylcarbamoyl-1-cyclohexylmethyl-2-hydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl ester 
• 114530-03-9 (2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide 
• 138571-24-1 4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide 
• 138571-28-5 N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide 
• 138571-25-2 4(S)-(acetylamino)-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide 
• 138571-23-0 4(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide 
• 138571-29-6 N-acetyl-L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide 
• 138571-27-4 L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide 
• 137999-91-8 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(S)-2-((R)-4-morpholin-4-yl-4-oxo-1-phenyl-butane-2-sulfonylmethyl)-hexanoylamino]-hexanoic acid butylamide 
• 137999-91-8 (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(R)-2-((S)-4-morpholin-4-yl-4-oxo-1-phenyl-butane-2-sulfonylmethyl)-hexanoylamino]-hexanoic acid butylamide 
• 143117-79-7 [(S)-1-((1S,2S,4S)-4-Butylcarbamoyl-1-cyclohexylmethyl-2-hydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester 
• 138662-94-9 3(S)-azido-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(S)-phenyl-1-piperidineacetamide 

Relevant articles and documents

Synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

A stereoselective synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid-n-butyl amide from Boc-L-phenylalanine is described.

Stereoselective Syntheses of Hydroxyethylene Dipeptide Isosteres

-

A Versatile and Stereocontrolled Synthesis of Hydroxyethylene Dipeptide Isosteres

An asymmetric synthesis of the hydroxyethylene dipeptide isostere unit 1 is described.The synthesis provides excellent stereocontrol over all three chiral centers and is amenable to variation of substituents R1 and R2.Key intermediat