114528-96-0

Basic information

• Product Name: trans,trans-(5S)-5-<9'-(2,3-bis((dimethylthexylsilyl)oxy)cyclohexyl)-3'-nonenyl>-2,3-dihydrofuranone
• CAS NO: 114528-96-0
• Molecular Weight: 609.094
• Mol File: 114528-96-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: trans,trans-(5S)-5-<9'-(2,3-bis((dimethylthexylsilyl)oxy)cyclohexyl)-3'-nonenyl>-2,3-dihydrofuranone(CAS DataBase Reference)
• NIST Chemistry Reference: trans,trans-(5S)-5-<9'-(2,3-bis((dimethylthexylsilyl)oxy)cyclohexyl)-3'-nonenyl>-2,3-dihydrofuranone(114528-96-0)
• EPA Substance Registry System: trans,trans-(5S)-5-<9'-(2,3-bis((dimethylthexylsilyl)oxy)cyclohexyl)-3'-nonenyl>-2,3-dihydrofuranone(114528-96-0)

Safety Data

• Hazardous Substances Data: 114528-96-0(Hazardous Substances Data)

Upstream product

• 99393-06-3 R-(-)-γ-bromomethylene-γ-butyrolactone 
• 114423-62-0 trans,trans-3-(6'-bromohexyl)-1,2-bis<(dimethylthexylsilyl)oxy>cyclohexane 
• 114423-59-5 3-<6'-(trimethylsilyloxy)hexyl>-1-<(trimethylsilyl)oxy>cyclohexene 
• 114423-61-9 trans,trans-3-(6'-bromohexyl)-1,2-cyclohexanediol 
• 114423-60-8 trans,trans-3-(6-hydroxyhexyl)-1,2-cyclohexanediol 
• 114423-69-7 (5S)-5-(3'butenyl)-tetrahydro-2-furanone 
• 26306-00-3 (6-bromohexyl)-trimethylsilyl ether 
• 4224-70-8 6-bromohexanoic acid 
• 4286-55-9 1-bromo-6-hexanol 
• 52813-63-5 (5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone 
• 114423-70-0 (5S)-5-(3'-oxopropyl)tetrahydro-2-furanone 
• 114423-63-1 <6'-(trans,trans-1'',2''-bis((dimethylthexylsilyl)oxy)-3''-cyclohexyl)hexyl>triphenylphosphonium bromide 

Downstream Products

• 114489-16-6 trans,trans-(5S)-5-<9'-(2,3-dihydroxycyclohexyl)-3'-nonenyl>-3-methylenetetrahydro-2-furanone 
• 114489-14-4 trans,trans-(5S)-5-<9'-(2,3-bis((dimethylthexylsilyl)oxy)cyclohexyl)-3'-nonenyl>-3-methylenetetrahydro-2-furanone 

Relevant articles and documents

Synthesis of a Model Hapten with Cyclohexanediol and &α-Methylene-&γ-butyrolactone Groups, a Synthetic Analogue of Poison Ivy and Tulipalin Allergens Connected with a Carbon Chain

Potential skin sensitizers 1 and 1* with two different haptenic ends, (a) a cyclohexanediol group (saturated poison ivy analogue ) and (b) an α-methylene-γ-butyrolactone moiety (tulipalin A), separated by a nine carbon atoms chain containing a double bond have been prepared.The trans, trans relationship in the substituted cyclohexanediol was secured by a tandem Michael addition-hydroboration reaction.Contrary to an earlier example of a double-headed hapten containing pyrocatechol and α-methylene-γ-butyrolactone ends, the cyclohexanediol-α-methylene-γ-butyrolactone does not show any tolerance induction to the α-methylene-γ-butyrolactone end.It therefore seems that induction of tolerance as well as sensitization requires the formation of covalent bond with a protein carrier.