1146191-80-1

Basic information

• Product Name: C₂₃H₂₇NO
• CAS NO: 1146191-80-1
• Molecular Weight: 333.473
• Mol File: 1146191-80-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₇NO(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₇NO(1146191-80-1)
• EPA Substance Registry System: C₂₃H₂₇NO(1146191-80-1)

Safety Data

• Hazardous Substances Data: 1146191-80-1(Hazardous Substances Data)

Upstream product

• 273727-89-2 3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one 
• 4452-06-6 1-(naphthalen-2-yl)prop-2-en-1-one 
• 76635-88-6 vinyl-2-naphthylcarbinol 
• 66-99-9 β-naphthaldehyde 

Relevant articles and documents

Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols

One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by γ-secretase. At the beginning of a series of studies from our laboratories, a series of novel γ-amino alcohols (1) were found to possess γ-secretase inhibitory activity and Notch-sparing effects. A new one-pot synthesis of γ-amino alcohols and the structure-activity relationship (SAR) of these analogs will be discussed.