4452-06-6

Basic information

• Product Name: ZM 449829
• Synonyms: ZM 449829;2-NAPHTHYLVINYL KETONE;1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE;JAK3 INHIBITOR V;2-Propen-1-one, 1-(2-naphthalenyl)-;1-Naphthalen-2-yl-propenone;1-(2-Naphthyl)-2-propen-1-one;2'-Acrylonaphthone
• CAS NO: 4452-06-6
• Molecular Formula: C₁₃H₁₀O
• Molecular Weight: 182.22
• Product Categories: Intracellular Signaling
• Mol File: 4452-06-6.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 319.3°C at 760 mmHg
• Flash Point: 137.5°C
• Appearance: /
• Density: 1.093g/cm³
• Vapor Pressure: 0.000342mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Desiccate at -20°C
• CAS DataBase Reference: ZM 449829(CAS DataBase Reference)
• NIST Chemistry Reference: ZM 449829(4452-06-6)
• EPA Substance Registry System: ZM 449829(4452-06-6)

Safety Data

• Hazardous Substances Data: 4452-06-6(Hazardous Substances Data)

Usage

Uses

ZM 449829, is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. Also inhibits STAT-5 phosphorylation and T-cell proliferation.

InChI:InChI=1/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2

Upstream product

• 22422-70-4 3-chloro-1-(naphthalen-2-yl)propan-1-one 
• 1590-22-3 4-(2-naphthyl)-4-oxobutyric acid 
• 1826-67-1 vinyl magnesium bromide 
• 113443-62-2 N-methoxy-N-methylnaphthalene-2-carboxamide 
• 76635-88-6 vinyl-2-naphthylcarbinol 
• 2243-83-6 2-naphthaloyl chloride 
• 50-00-0 formaldehyd 
• 893-33-4 4,4,4-trifluoro-1-(2-naphthyl)-1,3-butanedione 
• 66-99-9 β-naphthaldehyde 
• 93-08-3 methyl 2-naphthyl ketone 
• 127-19-5 N,N-dimethyl acetamide 
• 67-68-5 dimethyl sulfoxide 
• 67-56-1 methanol 

Downstream Products

• 273727-89-2 3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one 
• 1218988-68-1 (R)-1-(3-(naphthalen-2-yl)-3-oxopropyl)-2-oxocyclohexanecarbonitrile 
• 802266-53-1 3-(benzyl(methyl)amino)-1-(naphthalen-2-yl)propan-1-one 
• 1219024-52-8 2-(N-methylbenzyl)aminoethyl-4-benzylphenylketone 
• 1219024-51-7 2-(N-t-butylbenzyl)aminoethyl-4-benzylphenylketone 
• 1447138-08-0 N-benzyloxycarbonyl-(E)-4-(2-aminophenyl)-1-(naphthalen-2-yl)-2-en-1-one 
• 1450761-08-6 C₂₇H₂₃NO₂ 
• 1146190-52-4 3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-ol 
• 1146191-80-1 C₂₃H₂₇NO 
• 1146191-81-2 C₂₃H₂₇NO 

Relevant articles and documents

Silver oxide(I) promoted Conia-ene/radical cyclization for a straightforward access to furan derivatives

A novel access to fused furan cores using silver oxide(I) has been developed. Mechanistic investigations indicate the involvement of a Conia-ene reaction/radical cyclization for an expedient path to complex furan derivatives. The reaction is broad in scop

Nickel-Catalyzed C(sp3)-H Functionalization of Benzyl Nitriles: Direct Michael Addition to Terminal Vinyl Ketones

An efficient nickel(0)-catalyzed addition of benzyl nitriles to terminal vinyl ketones via C(sp3)-H functionalization has been developed. The reaction provides a novel and efficient protocol for the synthesis of α-functionalized benzyl nitriles with a wide range of structural diversity under mild reaction conditions while obviating the use of a strong base. The work might be potentially useful toward the development of an enantioselective variant using chiral nitrogen ligands.

Generation of α-Boryl Radicals and Their Conjugate Addition to Enones: Transition-Metal-Free Alkylation of gem-Diborylalkanes

A transition-metal-free method for the alkylation of gem-diborylalkanes with α,β-unsaturated ketones has been developed. It is demonstrated that the α-boryl radicals can be generated efficiently from gem-diborylalkanes with the aid of catechol and oxidants. The α-boryl radicals formed through such process can be engaged in conjugate addition reaction with α,β-unsaturated ketones. This transformation is a straightforward method for the synthesis of γ-borylketones.