114795-49-2

Basic information

• Product Name: 3-(cyclohexylmethyl)-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one
• Synonyms: 3-(cyclohexylmethyl)-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one
• CAS NO: 114795-49-2
• Molecular Weight: 357.493
• Mol File: 114795-49-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(cyclohexylmethyl)-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(cyclohexylmethyl)-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one(114795-49-2)
• EPA Substance Registry System: 3-(cyclohexylmethyl)-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one(114795-49-2)

Safety Data

• Hazardous Substances Data: 114795-49-2(Hazardous Substances Data)

Upstream product

• 21271-01-2 (6,7-dimethoxy-3,4-dihydro-isoquinolin-1-yl)-acetic acid ethyl ester 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 52244-03-8 ethyl 3-(1-(2-ethoxy-2-oxoethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propanoate 
• 79641-41-1 N-[2-(3,4-dimethoxyphenyl)ethyl]malonic acid ethyl ester amide 
• 5911-33-1 ethyl 9,10-dimethoxy-2-oxo-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-3-carboxylate 
• 14028-68-3 ethyl 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate 
• 50-00-0 formaldehyd 

Downstream Products

• 120639-04-5 3-(cyclohexylmethyl)-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol 

Relevant articles and documents

Synthesis and biological evaluation of 3-alkyl-dihydrotetrabenazine derivatives as vesicular monoamine transporter-2 (VMAT2) ligands

In the search of new probes for in vivo brain imaging of vesicular monoamine transporter type 2 (VMAT2), we have developed an efficient synthesis of a novel series of 3-alkyl-dihydrotetrabenazine (DTBZ) derivatives. The affinity of VMAT2 was evaluated by an in vitro inhibitory binding assay using [125I]-iodovinyl-TBZ or [18F](+)-FP-DTBZ as radioligands in rat striatal tissue homogenates. New DTBZ derivatives exhibited moderate to good binding affinity to VMAT2. Among these new ligands, compound 4b showed the best affinity for VMAT2 (Ki = 5.98 nM) and may be a useful lead compound for future structure-activity studies.