21271-01-2

Basic information

• Product Name: ethyl (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetate
• CAS NO: 21271-01-2
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.3157
• Mol File: 21271-01-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 395.7°C at 760 mmHg
• Flash Point: 166.3°C
• Density: 1.17g/cm³
• Vapor Pressure: 1.81E-06mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: ethyl (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetate(21271-01-2)
• EPA Substance Registry System: ethyl (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetate(21271-01-2)

Safety Data

• Hazardous Substances Data: 21271-01-2(Hazardous Substances Data)

Upstream product

• 112342-27-5 (6,7-dimethoxy-3,4-dihydro-2H-isoquinoline-1-ylidene)acetic acid ethyl ester 
• 79641-41-1 N-[2-(3,4-dimethoxyphenyl)ethyl]malonic acid ethyl ester amide 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 105-53-3 diethyl malonate 

Downstream Products

• 128642-05-7 (8,9-Dimethoxy-1,3-diphenyl-5,6-dihydro-1H-[1,2,4]triazolo[3,4-a]isoquinolin-10b-yl)-acetic acid ethyl ester 
• 128642-09-1 10b-Ethoxycarbonylmethyl-8,9-dimethoxy-1-phenyl-1,5,6,10b-tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline-3-carboxylic acid ethyl ester 
• 14028-68-3 ethyl 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate 
• 120639-04-5 3-(cyclohexylmethyl)-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol 
• 114795-49-2 3-(cyclohexylmethyl)-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one 

Relevant articles and documents

Synthesis and biological evaluation of 3-alkyl-dihydrotetrabenazine derivatives as vesicular monoamine transporter-2 (VMAT2) ligands

In the search of new probes for in vivo brain imaging of vesicular monoamine transporter type 2 (VMAT2), we have developed an efficient synthesis of a novel series of 3-alkyl-dihydrotetrabenazine (DTBZ) derivatives. The affinity of VMAT2 was evaluated by an in vitro inhibitory binding assay using [125I]-iodovinyl-TBZ or [18F](+)-FP-DTBZ as radioligands in rat striatal tissue homogenates. New DTBZ derivatives exhibited moderate to good binding affinity to VMAT2. Among these new ligands, compound 4b showed the best affinity for VMAT2 (Ki = 5.98 nM) and may be a useful lead compound for future structure-activity studies.