114797-74-9

Basic information

• Product Name: C₃₆H₃₆N₃O₉P
• CAS NO: 114797-74-9
• Molecular Weight: 685.67
• Mol File: 114797-74-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: C₃₆H₃₆N₃O₉P(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₃₆N₃O₉P(114797-74-9)
• EPA Substance Registry System: C₃₆H₃₆N₃O₉P(114797-74-9)

Safety Data

• Hazardous Substances Data: 114797-74-9(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 130288-81-2 5'-O-dimethoxytrityl-2'-deoxythymidine-3'-H-phosphonate 
• 102987-82-6 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl methyl phosphonate 
• 3868-27-7 triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 170638-52-5 5'-O-(dimethoxytrityl)thymidin-3'-yl (trimethylsilyl)-H-phosphonate 

Relevant articles and documents

New methods for multiple modifications of a phosphorus centre. Their relevance to nucleotide and oligonucleotide analogues synthesis

Nucleoside phosphoramidates and their analogues with the P-N bond in bridging positions of the phosphoramidate linkage were prepared by a new method utilizing the corresponding pyridine adducts of metaphosphates. Also, a new procedure was developed for the synthesis of unprotected nucleoside phosphoromono- and phosphorodithioates.

A facile access to nucleoside phosphorofluoridate, nucleoside phosphorofluoridothioate, and nucleoside phosphorofluoridodithioate monoesters

Oxidation of H-phosphonate, H-phosphonothioate, or H-phosphonodithioate monoesters with iodine in pyridine in the presence of trimethylsilyl chloride, followed by addition of triethylamine trishydrofluoride (TAF) furnished rapid and quantitative formation of the corresponding phosphorofluoridate, phosphorofluoridothioate, or phosphorofluoridodithioate monoesters.

Nucleoside Phosphonates: Part 7. Studies on the Oxidation of Nucleoside Phosphonate Esters

Oxidation of phosphonate mono- and di-esters with various oxidizing agents including diaryl disulphides, hexacloroacetone, and iodine, has been investigated under various reaction conditions.The most efficient oxidation procedure consists of treatment of phosphonate esters with iodine in pyridine-water.When the phosphonate esters were presilylated by treatment with trimethylsilyl chloride, the subsequent oxidation with aqueous iodine was faster. (31)P N.m.r. spectroscopic studies have enabled us to propose the most likely pathway for the majority of the oxidations.