170638-52-5

Basic information

• Product Name: 5'-O-(dimethoxytrityl)thymidin-3'-yl (trimethylsilyl)-H-phosphonate
• CAS NO: 170638-52-5
• Molecular Weight: 680.767
• Mol File: 170638-52-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5'-O-(dimethoxytrityl)thymidin-3'-yl (trimethylsilyl)-H-phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(dimethoxytrityl)thymidin-3'-yl (trimethylsilyl)-H-phosphonate(170638-52-5)
• EPA Substance Registry System: 5'-O-(dimethoxytrityl)thymidin-3'-yl (trimethylsilyl)-H-phosphonate(170638-52-5)

Safety Data

• Hazardous Substances Data: 170638-52-5(Hazardous Substances Data)

Upstream product

• 3868-27-7 triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 75-77-4 chloro-trimethyl-silane 
• 130288-81-2 5'-O-dimethoxytrityl-2'-deoxythymidine-3'-H-phosphonate 
• 135704-44-8 C₃₆H₄₁N₂O₁₀P 

Downstream Products

• 114797-74-9 C₃₆H₃₆N₃O₉P 

Relevant articles and documents

Efficient Method for the Preparation of Nucleoside Phosphorofluoridates and Nucleoside Phosphorofluoridothioates

Dinucleoside H-phosphonates and nucleoside H-phosphonothioates can be efficiently transformed to the fluorophosphate and fluorothiophosphate diester derivatives via iodine promoted oxidation in the presence of fluoride anions.An analogous oxidation of the

Nucleoside H-phosphonates. 15. Preparation of nucleoside H-phosphonothioate monoesters from the corresponding nucleoside H-phosphonates

A convenient method for the preparation of nucleoside 3'-H-phosphonothioate monoesters from suitably protected nucleoside 3'-H-phosphonates has been developed. It consists of activation of nucleoside H-phosphonates with pivaloyl chloride in the presence of a limited amount of a base followed by treatment with 1,1,1,3,3,3-hexamethyldisilathiane (HMDST).