114980-27-7

Basic information

• Product Name: 4-<3-(dibutylamino)propoxy>benzaldehyde
• Synonyms: 4-<3-(dibutylamino)propoxy>benzaldehyde
• CAS NO: 114980-27-7
• Molecular Weight: 291.434
• Mol File: 114980-27-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-<3-(dibutylamino)propoxy>benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-<3-(dibutylamino)propoxy>benzaldehyde(114980-27-7)
• EPA Substance Registry System: 4-<3-(dibutylamino)propoxy>benzaldehyde(114980-27-7)

Safety Data

• Hazardous Substances Data: 114980-27-7(Hazardous Substances Data)

Upstream product

• 36421-15-5 dibutyl-(3-chloro-propyl)-amine 
• 123-08-0 4-hydroxy-benzaldehyde 
• 115555-77-6 1-chloro-3-(di-n-butylamino)-propane hydrochloride 

Downstream Products

• 114979-70-3 Dibutyl-(3-{4-[(E)-2-(1-methyl-1H-benzoimidazol-2-yl)-vinyl]-phenoxy}-propyl)-amine 
• 141644-94-2 N-(2-butyl-3-{[4-(3-dibutylaminopropoxy)-phenyl]-hydroxymethyl}-benzofuran-5-yl)-methanesulfonamide 
• 141626-36-0 dronedarone 
• 114980-22-2 2-<4-<3-(dibutylamino)propoxy>phenyl>benzimidazole 
• 114979-68-9 (E)-2-<2-<4-<3-(dibutylamino)propoxy>phenyl>ethenyl>benzimidazole 

Relevant articles and documents

Concise total synthesis of antiarrhythmic drug dronedarone via a conjugate addition followed intramolecular heck cyclization

A concise, scalable, and an efficient total synthesis for dronedarone (2) was described using conjugate addition followed by intramolecular Heck cyclization. The other key reaction includes selective reduction of nitro functionality and addition of lithiated terminal alkyne to the aldehyde. The overall yield of this approach is 44% in six steps.