1152313-75-1

Basic information

• Product Name: (S)-2-(2-fluorophenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole
• Synonyms: (S)-2-(2-fluorophenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole
• CAS NO: 1152313-75-1
• Molecular Weight: 235.301
• Mol File: 1152313-75-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-(2-fluorophenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(2-fluorophenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole(1152313-75-1)
• EPA Substance Registry System: (S)-2-(2-fluorophenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole(1152313-75-1)

Safety Data

• Hazardous Substances Data: 1152313-75-1(Hazardous Substances Data)

Upstream product

• 157035-77-3 tert-butyl (S)-(2-hydroxy-2,4-dimethylpentan-3-yl)carbamate 
• 6306-52-1 L-valine methylester hydrochloride 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 
• 72-18-4 L-valine 
• 1152313-74-0 (S)-2-fluoro-N-(2-hydroxy-2,4-dimethylpentan-3-yl)benzamide 

Downstream Products

• 1152313-76-2 (4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-dimethyl-4-(1-methylethyl)-oxazole 
• 1350923-52-2 C₂₈H₃₂NOP 

Relevant articles and documents

Design, synthesis, and applications of potential substitutes of t-Bu-phosphinooxazoline in Pd-catalyzed asymmetric transformations and their use for the improvement of the enantioselectivity in the Pd-catalyzed allylation reaction of fluorinated allyl enol carbonates

The design, synthesis, and applications of potential substitutes of t-Bu-PHOX in asymmetric catalysis is reported. The design relies on the incorporation of geminal substituents at C5 in combination with a substituent at C4 other than t-butyl (i-Pr, i-Bu, or s-Bu). Most of these new members of the PHOX ligand family behave similarly in terms of stereoinduction to t-Bu-PHOX in three palladium-catalyzed asymmetric transformations. Electronically modified ligands were also prepared and used to improve the enantioselectivity in the Pd-catalyzed allylation reaction of fluorinated allyl enol carbonates.