115290-78-3

Basic information

• Product Name: 1,3-Propanediol, 1-phenyl-, 3-methanesulfonate, (1R)-
• CAS NO: 115290-78-3
• Molecular Formula: C10H14O4S
• Molecular Weight: 230.285
• Mol File: 115290-78-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Propanediol, 1-phenyl-, 3-methanesulfonate, (1R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanediol, 1-phenyl-, 3-methanesulfonate, (1R)-(115290-78-3)
• EPA Substance Registry System: 1,3-Propanediol, 1-phenyl-, 3-methanesulfonate, (1R)-(115290-78-3)

Safety Data

• Hazardous Substances Data: 115290-78-3(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 100-52-7 benzaldehyde 
• 72656-47-4 ethyl (R)-3-hydroxy-3-phenylpropanoate 
• 5764-85-2 Ethyl 3-hydroxy-3-phenylpropanoate 
• 118856-08-9 butyric acid 2-ethoxycarbonyl-1-phenyl-ethyl ester 
• 104196-23-8 (2S,3S)-2,3-epoxy-3-phenyl-1-propanol 

Downstream Products

• 82857-39-4 -(+)-tomoxetine hydrochloride 
• 105314-53-2 (S)-N-methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine 
• 54910-89-3 (R)-fluoxetine 
• 115290-81-8 (R)-N-methyl-3-phenyl-3-hydroxypropylamine 
• 138750-31-9 (1R)-3-amino-1-phenyl-1-propanol 
• 115290-80-7 (3S) 3-phenyl-3-(2-methylphenoxy)propyl methanesulfonate 

Relevant articles and documents

Candida Rugosa lipase-catalyzed kinetic resolution of β-hydroxy- β-arylpropionates and δ-hydroxy-δ-aryl-β-oxo-pentanoates

A simple and convenient method was reported for the preparation of optically active β-hydroxy-β-arylpropionates, δ-hydroxy-δ- aryl-β-oxo-pentanoates and their butyryl derivatives via CRL-catalyzed hydrolysis. The optically active products are potential precursors of some chiral pharmaceuticals and natural products.

Asymmetric Synthesis of Both Enantiomers of Tomoxetine and Fluoxetine. Selective Reduction of 2,3-Epoxycinnamyl Alcohol with Red-Al.

Both enantiomers of tomoxetine 7a,7b and fluoxetine 8a,8b (as their hydrochloride salts) have been synthetized from cinnamyl alkohol by asymmetric epoxidation, and their absolute configurations have been established.Optimal conditions for regioselective Red-Al reduction at C-2 of 2,3-epoxycinnamyl alcohol are discussed.