115505-09-4

Basic information

• Product Name: Ethanone, 2-(ethylthio)-1-(4-methoxyphenyl)-
• CAS NO: 115505-09-4
• Molecular Formula: C11H14O2S
• Molecular Weight: 210.297
• Mol File: 115505-09-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(ethylthio)-1-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(ethylthio)-1-(4-methoxyphenyl)-(115505-09-4)
• EPA Substance Registry System: Ethanone, 2-(ethylthio)-1-(4-methoxyphenyl)-(115505-09-4)

Safety Data

• Hazardous Substances Data: 115505-09-4(Hazardous Substances Data)

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 542-90-5 ethyl isothiocyanate 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 75-08-1 ethanethiol 
• 41068-36-4 2-chloro-4-methoxyacetophenone 
• 811-51-8 sodium thioethylate 

Downstream Products

• 1391948-71-2 1-ethyl-2-((4-methoxyphenyl)ethynyl)sulfane 
• 139268-81-8 2-Ethanesulfinyl-1-(4-methoxy-phenyl)-ethanone 
• 139268-87-4 2-Ethanesulfonyl-1-(4-methoxy-phenyl)-ethanone 

Relevant articles and documents

One-pot preparation of arylethynyl sulfides and bis(arylethynyl) sulfides

An efficient preparation for arylethynyl sulfides 1 and bis(arylethynyl) sulfides 2 has been accomplished through a one-pot, three-step strategy that starts from arylethanonyl sulfides and bis(arylethanonyl) sulfides, respectively, without the use of various terminal arylacetylenes as substrates. When lithium hexamethyldisilazane (LHMDS), ClP(O)(OEt)2, and LHMDS were sequentially added to a tetrahydrofuran solution of different substrates [arylethanonyl sulfides or bis(arylethanonyl) sulfides], 1 or 2 were obtained in moderate to good yields. The reaction procedure involves the formation of an enol phosphate and a subsequent base-induced elimination. An efficient preparation of arylethynyl sulfides 1 and bis(arylethynyl) sulfides 2 has been accomplished by a one-pot, three-step strategy that starts from arylethanonyl sulfides and bis(arylethanonyl) sulfides, respectively, to give 1 and 2 in moderate to good yields. The reaction mechanism involves the formation of an enol phosphate that undergoes a subsequent base-induced elimination. Copyright

Trithiocarbonates-Exploration of a new head group for HDAC inhibitors

Inhibition of histone deacetylases class I/II enzymes is a new, promising approach for cancer therapy. In the present study, we disclose a new structural class of HDAC inhibitors with the trithiocarbonate motif. A clear structure-activity-relationship was obtained for the cap-linker motif and the putative Zn2+ complexing head group. Selected analogs display potent inhibition of HDAC enzymatic activity and a cellular potency comparable to that of suberoylanilide hydroxamic acid (SAHA), recently approved for treatment of patients with advanced cutaneous T-cell lymphoma.