41068-36-4 Usage
Description
2'-CHLORO-4'-HYDROXYACETOPHENONE, also known as 1-(2-Chloro-4-hydroxyphenyl)ethanone, is an organic compound with the molecular formula C8H7ClO2. It is a derivative of acetophenone, featuring a chlorine atom at the 2' position and a hydroxyl group at the 4' position. 2'-CHLORO-4'-HYDROXYACETOPHENONE is known for its potential applications in various industries, particularly in the pharmaceutical sector.
Uses
Used in Pharmaceutical Industry:
2'-CHLORO-4'-HYDROXYACETOPHENONE is used as a key intermediate compound for the synthesis of aminopyrazine compounds, which serve as HPK1 inhibitors. These HPK1 inhibitors play a crucial role in modulating various cellular signaling pathways and have potential therapeutic applications in treating different diseases.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2'-CHLORO-4'-HYDROXYACETOPHENONE can be utilized as a building block for the development of novel compounds with diverse applications. Its unique structural features make it a valuable component in the design and synthesis of new molecules with potential pharmaceutical, agrochemical, or material science applications.
Preparation
Obtained by reaction of acetyl chloride with 3-chloroanisole in the presence of aluminium chloride (55%), in carbon disulfide (62%) or in 1,2-dichloroethane (81%).
Check Digit Verification of cas no
The CAS Registry Mumber 41068-36-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,0,6 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 41068-36:
(7*4)+(6*1)+(5*0)+(4*6)+(3*8)+(2*3)+(1*6)=94
94 % 10 = 4
So 41068-36-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H9ClO2/c1-6(11)8-4-3-7(12-2)5-9(8)10/h3-5H,1-2H3
41068-36-4Relevant articles and documents
Catalytic Friedel-Crafts acylation of aromatic ethers using Sml3
Chen, Xiaohang,Yu, Mingxin,Wang, Meijun
, p. 80 - 81 (2007/10/03)
10% mol Sml3 catalysed the Friedel-Crafts acylation of aromatic ethers by acyl chlorides in acetonitrile with the yields of 48-82%. Reactions of various substituted aromatic ethers with acyl chloride were studied. The structures of compounds were established by IR and 1H NMR. The main product obtained with anisole is the para-substituted compound with only a trace (3, a pattern repeated with the other aromatic ethers used.
Aqua(sulfato)platinum(II) Complexes with Variable Substituents in the 2-Phenyl Ring. 1. Synthesis and Antitumor and Estrogenic Properties
Gust, Ronald,Burgemeister, Thomas,Mannschreck, Albrecht,Schoenenberger, Helmut
, p. 2535 - 2544 (2007/10/02)
Erythro- and threo-configurated aqua(sulfato)platinum(II) complexes with variable substituents in the 2-phenyl ring (2-PtSO4 to 9-PtSO4: H, 4-F, 3-OH, 4-OH, 2,6-F2, 2,6-Cl2, 2-F/4-OH, 2-Cl/4-OH) were synthesized and tested for estrogenic and antitumor activities.The ligands were obtained by a three-step reaction.The stilbenes were reacted with a mixture of IN3 and NaN3 to yield the respective 1,2-diazido-1,2-diphenylethanes.The subsequent reduction with LiAlH4 led to the corresponding 1,2-diphenylethylenediamines.The (sulfato)platinum(II) complexes were synthesized by reaction of Ag2SO4 with the diiodo complexes, which had been obtained by coordination of the diamines with K2PtI4.Two complexes, erythro-8-PtSO4 and erythro-9-PtSO4, possess antitumor and estrogenic effects and are therefore of interest for the therapy of breast cancer.
