115974-96-4

Basic information

• Product Name: Benzoic acid, 3-[(1E)-3-methoxy-3-oxo-1-propenyl]-
• CAS NO: 115974-96-4
• Molecular Formula: C11H10O4
• Molecular Weight: 206.198
• Mol File: 115974-96-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-[(1E)-3-methoxy-3-oxo-1-propenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-[(1E)-3-methoxy-3-oxo-1-propenyl]-(115974-96-4)
• EPA Substance Registry System: Benzoic acid, 3-[(1E)-3-methoxy-3-oxo-1-propenyl]-(115974-96-4)

Safety Data

• Hazardous Substances Data: 115974-96-4(Hazardous Substances Data)

Upstream product

• 585-76-2 m-bromobenzoic acid 
• 292638-85-8 acrylic acid methyl ester 
• 5927-18-4 trimethyl phosphonoacetate 
• 619-21-6 m-formylphenyl benzoic acid 

Downstream Products

• 1018674-33-3 cyclopentyl (2S)-cyclohexyl[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzoyl)amino]acetate 
• 1018674-31-1 methyl (2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylate 
• 1018674-32-2 (2E)-3-(3-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]carbamoyl}phenyl)acrylic acid 
• 23746-59-0 (E)-3-[3-((E)-2-methoxycarbonyl-vinyl)-phenyl]-acrylic acid methyl ester 
• 581799-33-9 3-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]benzoic acid chloride 

Relevant articles and documents

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors

In order to take advantage of both immunotherapeutic and epigenetic antitumor agents, the first generation of dual indoleamine 2,3-dioxygenase 1 (IDO1) and histone deacetylase (HDAC) inhibitors were designed. The highly active dual inhibitor 10 showed exc

HDAC INHIBITORS

Compounds of formula (I) inhibit HDAC activity, wherein A, B and D independently represent =C- or =N-; W is a divalent radical -CH=CH- or CH2CH2-; R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; z is 0 or 1; and Y, L1, and X1 are as defined in the claims.