116003-78-2Relevant articles and documents
Synthesis of 1,2,3-triazolyl analog of Neisseria meningitidis A capsular polysaccharide
Vangala, Madhuri,Hotha, Srinivas
, p. 393 - 413 (2018)
Towards constructing a stable, non-hydrolyzable linkage for Neisseria meningitidis type A (MenA) polysaccharide, the phosphate bridge of its (1→6)-linked 2-acetamido-2-deoxy-α-D-mannopyranosyl phosphate repeating unit was replaced by a triazolyl analog using Cu(I) catalyzed click reaction. The synthesis involved anomeric azidation of N-acetyl-D-mannosamine derivative from its acetate precursor using stoichiometric amount of FeCl3 and one-pot synthesis of precursors for di- and tri- triazolyl saccharides with an azidoethyl spacer at the reducing end for bioconjugation.
Modular hydroxyamide and thioamide pyranoside-based ligand library from the sugar pool: New class of ligands for asymmetric transfer hydrogenation of ketones
Coll, Mercè,Pàmies, Oscar,Diéguez, Montserrat
supporting information, p. 2293 - 2302 (2014/07/21)
A large library of pyranoside-based hydroxyamide and thioamide ligands has been synthesized for asymmetric transfer hydrogenation in an attempt to expand the scope of the substrates to cover a broader range of challenging heteroaromatic and aryl/fluoroalkyl ketones. These ligands have the advantage that they are prepared from commercial D-glucose, D-glucosamine and α-amino acids, inexpensive natural chiral feedstocks. By carefully selecting the ligand components (substituents/configurations at the amide/thioamide moiety, the position of amide/thioamide group and the configuration at C-2), we found that pyranoside-based thioamide ligands provided excellent enantioselectivities (in the best cases, ees of >99% were achieved) in a broad range of ketones, including the less studied heteroaromatics and challenging aryl/fluoroalkyls. Note that both enantiomers of the reduction products can be obtained with excellent enantioselectivities by simply changing the absolute configuration of the thioamide substituent.
Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid
Hartlieb, Sina,Guenzel, Almut,Gerardy-Schahn, Rita,Muenster-Kuehnel, Anja K.,Kirschning, Andreas,Draeger, Gerald
, p. 2075 - 2082 (2008/12/21)
7-Fluoro sialic acid was prepared and activated as cytidine monophosphate (CMP) ester. The synthesis started with d-glucose, which was efficiently converted into N-acetyl-4-fluoro-4-deoxy-d-mannosamine. Aldolase catalyzed transformation yielded the corres