635292-85-2 Usage
Chemical class
Belongs to the class of azides and glycosides.
Structure
Contains a synthetic sugar derivative with four acetyl groups, an azide group, and a deoxyhexose ring structure.
Stereochemistry
β-D-mannopyranose configuration.
Functional groups
Acetyl groups (4), azide group (1), and deoxyhexose ring (1).
Carbohydrate chemistry
Used for the synthesis of complex oligosaccharides and glycoconjugates.
Chemical biology
Useful for labeling and modifying biomolecules.
Bioorthogonal chemistry
Employed in research involving selective reactions that do not interfere with native biochemical processes.
Drug development
Potential applications in the development of new pharmaceuticals.
Carbohydrate-protein interactions
Serves as a tool for studying the interactions between carbohydrates and proteins.
Solubility
Generally soluble in organic solvents such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF), and methanol.
Stability
Stable under normal laboratory conditions, but sensitive to hydrolysis and should be stored desiccated and protected from light.
Hazards
Azide-containing compounds can be hazardous due to their potential to form explosive byproducts. Handle with care and follow proper safety protocols.
Purity
Typically provided with a high degree of purity, often >95% as determined by nuclear magnetic resonance (NMR) spectroscopy or high-performance liquid chromatography (HPLC).
Analytical techniques
Characterized using techniques such as NMR, HPLC, and mass spectrometry (MS) to confirm its structure and purity.
Check Digit Verification of cas no
The CAS Registry Mumber 635292-85-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,5,2,9 and 2 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 635292-85:
(8*6)+(7*3)+(6*5)+(5*2)+(4*9)+(3*2)+(2*8)+(1*5)=172
172 % 10 = 2
So 635292-85-2 is a valid CAS Registry Number.
635292-85-2Relevant articles and documents
Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis
Medve, Laura,Achilli, Silvia,Guzman-Caldentey, Joan,Thépaut, Michel,Senaldi, Luca,Le Roy, Aline,Sattin, Sara,Ebel, Christine,Vivès, Corinne,Martin-Santamaria, Sonsoles,Bernardi, Anna,Fieschi, Franck
, p. 14659 - 14668 (2019)
Chemical modification of pseudo-dimannoside ligands guided by fragment-based design allowed for the exploitation of an ammonium-binding region in the vicinity of the mannose-binding site of DC-SIGN, leading to the synthesis of a glycomimetic antagonist (compound 16) of unprecedented affinity and selectivity against the related lectin langerin. Here, the computational design of pseudo-dimannoside derivatives as DC-SIGN ligands, their synthesis, their evaluation as DC-SIGN selective antagonists, the biophysical characterization of the DC-SIGN/16 complex, and the structural basis for the ligand activity are presented. On the way to the characterization of this ligand, an unusual bridging interaction within the crystals shed light on the plasticity and potential secondary binding sites within the DC-SIGN carbohydrate recognition domain.
