116256-35-0Relevant articles and documents
Synthesis of corticoids from 9α-hydroxyandrost-4-ene-3,17-dione
Carruthers,Garshasb,McPhail
, p. 961 - 965 (1992)
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Preparation method of 17-alpha hydroxynitrile steroid derivative
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, (2018/03/28)
The invention relates to a preparation method of a steroid derivative, in particular to a preparation method of a 17-alpha hydroxynitrile steroid derivative, comprising: using 3,17-dione steroid compound (I) as a material, allowing it to react with acetone cyanohydrin in a solution of weak organic base to obtain 17-beta hydroxynitrile steroid derivative (II) as an intermediate (II), and allowing the intermediate (II) to react with hydroxynitrile in a strong base solution to obtain the 17-alpha hydroxynitrile steroid derivative (III). The materials for the preparation method are easy to obtain,the preparation method is simple to perform, side reactions can be effectively controlled, and reaction yield and weight can be increased; the preparation method does not involve high-danger reactions, and the preparation method is easy to industrialize, and is free of high-pollution reactions so that environmental treatment burden is relieved.
17β-cyano-9α,17α-dihydroxyandrost-4-en-3-one
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, (2008/06/13)
The invention is the compound 17β-cyano-9α, 17α-dihydroxyandrost-4-en-3-one (I) which is particularly useful as an intermediate in the production of the 17α-halo silyl ethers (II).