75-86-5Relevant articles and documents
A safe production method for acetone cyanohydrin
Heugebaert, Thomas S.A.,Roman, Bart I.,De Blieck, Ann,Stevens, Christian V.
, p. 4189 - 4191 (2010)
An easily amenable method is presented to produce acetone cyanohydrin on mole scale (output 39 g/h), using a continuous flow system to overcome the high risks associated with the large-scale use of hydrogen cyanide.
Anchimeric-Assisted Spontaneous Hydrolysis of Cyanohydrins Under Ambient Conditions: Implications for Cyanide-Initiated Selective Transformations
Yerabolu, Jayasudhan Reddy,Liotta, Charles L,Krishnamurthy, Ramanarayanan
supporting information, p. 8756 - 8765 (2017/06/30)
Nitrile/cyanide hydrolysis is of importance from the perspective of organic chemistry, especially, prebiotic chemistry. Herein we report that cyanohydrins, generated by the reaction of cyanide with β-keto acids and γ-keto-alcohols, spontaneously hydrolyze
Metal bridging for directing and accelerating electron transfer as exemplified by harnessing the reactivity of AIBN
Xie, Yinjun,Guo, Shengmei,Wu, Longmin,Xia, Chungu,Huang, Hanmin
supporting information, p. 5900 - 5904 (2015/05/13)
A new strategy for tuning the electron transfer between radicals and enolates has been developed. This method elicits the innate reactivity of AIBN with a copper catalyst and enables a cascade reaction with cinnamic acids. Electron paramagnetic resonance studies and control experiments indicate that the redox-active copper species not only activates the radical by coordination, but also serves as a bridge to bring the radical and nucleophile within close proximity to facilitate electron transfer. By exploiting possible combinations of redox-active metals and radical entities with suitable coordinating functional groups, this strategy should contribute to the development of a broad range of radical-based reactions.
Synthesis and evaluation of anti-inflammatory and antitussive activity of hydantion derivatives
Lu, Haibin,Kong, Dejuan,Wu, Bin,Wang, Shihan,Wang, Yongsheng
experimental part, p. 638 - 642 (2012/08/28)
1-Methylhydantion is a compound, which was isolated from Oviductus Ranae for the first time. In our study, we found that it showed good antitussive and anti-inflammatory activity. It is also the first report which illustrates the antitussive activity of hydantion derivative. A series of hydantion derivatives were synthesized and evaluated for their anti-inflammatory and antitussive activity in vivo. The pharmacological tests showed that compounds 7a, 7c and 7d have good anti-inflammatory and antitussive activity compared to Ibuprofen and codeine. Compound 7a in particular showed two-fold stronger anti-inflammatory activity than Ibuprofen.