1163681-53-5

Basic information

• Product Name: 3-chloro-2-iodo-1-methylpyridinium iodide
• Synonyms: 3-chloro-2-iodo-1-methylpyridinium iodide
• CAS NO: 1163681-53-5
• Molecular Formula: C₆H₆ClIN*I
• Molecular Weight: 381
• Mol File: 1163681-53-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-chloro-2-iodo-1-methylpyridinium iodide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-2-iodo-1-methylpyridinium iodide(1163681-53-5)
• EPA Substance Registry System: 3-chloro-2-iodo-1-methylpyridinium iodide(1163681-53-5)

Safety Data

• Hazardous Substances Data: 1163681-53-5(Hazardous Substances Data)

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 13466-35-8 3-chloropyridin-2(1H)-one 
• 1163681-55-7 N-[3-chloro-1-methylpyridin-2(1H)-ylidene]-4-methoxyaniline 
• 1163681-56-8 N-[3-chloro-1-methylpyridin-2(1H)-ylidene]-4-nitroaniline 
• 1163681-54-6 N-[3-chloro-1-methylpyridin-2(1H)-ylidene]aniline 

Relevant articles and documents

Synthesis of α-carbolines starting from 2,3-dichloropyridines and substituted anilines

9H-α-Carbolines have been prepared via consecutive intermolecular Buchwald-Hartwig reaction and Pd-catalyzed intramolecular direct arylation from commercially available 2,3-dichloropyridines and substituted anilines. The combination of a high reaction temperature (180°C) and the use of DBU were found to be crucial for the intramolecular direct arylation reactions of the 3-chloro-N-phenylpyridin-2-amines as no reaction was observed at 120°C and 180°C using different inorganic and other organic bases. On the other hand, nitrogen-methylated pyridine analogues of these substrates {N-[3-chloro-1- methylpyridin-2(1H)-ylidene]anilines} do undergo ring closure at 120°C, with K3PO4 as base, affording the respective 1-methyl-1H-α-carbolines in good yields.