1164-81-4

Basic information

• Product Name: 4-Chloropregn-4-ene-3,20-dione
• Synonyms: 4-Chloropregn-4-ene-3,20-dione;4-Chloroprogesterone
• CAS NO: 1164-81-4
• Molecular Formula: C21H29ClO2
• Molecular Weight: 0
• Mol File: 1164-81-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 462.4°C at 760 mmHg
• Flash Point: 194.5°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 9.89E-09mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 4-Chloropregn-4-ene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloropregn-4-ene-3,20-dione(1164-81-4)
• EPA Substance Registry System: 4-Chloropregn-4-ene-3,20-dione(1164-81-4)

Safety Data

• Hazardous Substances Data: 1164-81-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H29ClO2/c1-12(23)14-6-7-15-13-4-5-17-19(22)18(24)9-11-21(17,3)16(13)8-10-20(14,15)2/h13-16H,4-11H2,1-3H3/t13-,14+,15-,16-,20+,21+/m0/s1

Upstream product

• 17597-24-9 (4β,5)-epoxy-5β-pregnan-3,20-dione 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 1164-27-8 4(α,β),5-epoxypregnyne-3,20-dione 
• 57-83-0 Progesterone 

Downstream Products

• 1448329-09-6 21E-benzylidene-4-chloropregn-1,4-diene-3,20-dione 
• 1448329-10-9 21E-(2-chlorobenzylidene)-4-chloro-pregn-1,4-diene-3,20-dione 
• 1448329-11-0 21E-(4-chlorobenzylidene)-4-chloropregn-1,4-diene-3,20-dione 
• 1448329-12-1 21E-(2-methoxybenzylidene)-4-chloropregn-1,4-diene-3,20-dione 
• 1448329-13-2 21E-(4-methoxybenzylidene)-4-chloropregn-1,4-diene-3,20-dione 
• 1448329-14-3 21E-(2-nitrobenzylidene)-4-chloropregn-1,4-diene-3,20-dione 
• 1448329-15-4 21E-(4-methylbenzylidene)-4-chloropregn-1,4-diene-3,20-dione 

Relevant articles and documents

Multiple Enone-Directed Reactivity Modes Lead to the Selective Photochemical Fluorination of Polycyclic Terpenoid Derivatives

In the realm of aliphatic fluorination, the problem of reactivity has been very successfully addressed in recent years. In contrast, the associated problem of selectivity, that is, directing fluorination to specific sites in complex molecules, remains a great, fundamental challenge. In this report, we show that the enone functional group, upon photoexcitation, provides a solution. Based solely on orientation of the oxygen atom, site-selective photochemical fluorination is achieved on steroids and bioactive polycycles with up to 65 different sp3 C-H bonds. We have also found that γ-, β-, homoallylic, and allylic fluorination are all possible and predictable through the theoretical modes reported herein. Lastly, we present a preliminary mechanistic hypothesis characterized by intramolecular hydrogen atom transfer, radical fluorination, and ultimate restoration of the enone. In all, these results provide a leap forward in the design of selective fluorination of complex substrates that should be relevant to drug discovery, where fluorine plays a prominent role.

Synthesis and cytotoxic activity of some novel steroidal C-17 pyrazolinyl derivatives

Fourteen novel steroidal C-17 pyrazolinyl derivatives 9a-g and 10a-g were synthesized from commercially available progesterone and tested for their cytotoxic activity against brine shrimp (Artemia salina) and three human cancer cell lines (NCI-H460, HeLa, and HepG2). Some of these synthetic compounds exhibited significant cytotoxic activity, and treatment of HeLa cells with compound 10b resulted in the cell population arrest in the S phase. A structure-activity relationship was discussed.